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101 Results for "

PKC β

" in MedChemExpress (MCE) Product Catalog:

Products (101)

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Go 6983

94 Publications Verification

Cat. No.: HY-13689

CAS No.: 133053-19-7

Purity: 99.32%

Synonyms: Gö 6983; Goe 6983

Target:

PKC

Research Areas:

Cancer

Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC₅₀ of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.

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BX795

42 Cited Publications

Cat. No.: HY-10514

CAS No.: 702675-74-9

Purity: 99.84%

Target:

PDK-1 IKK Autophagy

Research Areas:

Cancer

BX795 is a potent and selective inhibitor of PDK1, with an IC₅₀ of 6 nM. BX795 is also a potent and relatively specific inhibitor of TBK1 and IKKε, with an IC₅₀ of 6 and 41 nM, respectively. BX795 blocks phosphorylation of S6K1, Akt, PKCδ, and GSK3β, and has lower selectivity over PKA, PKC, c-Kit, GSK3β etc. BX795 modulates autophagy .

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Midostaurin

40 Cited Publications

Cat. No.: HY-10230

CAS No.: 120685-11-2

Purity: 99.91%

Synonyms: PKC412; CGP 41251

Target:

PKC VEGFR c-Kit NO Synthase Apoptosis

Research Areas:

Cancer

Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .

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