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33 Results for "

PLC cells

" in MedChemExpress (MCE) Product Catalog:

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Neomycin sulfate

82 Publications Verification

Cat. No.: HY-B0470

CAS No.: 1405-10-3

Category:

Disease Research Antibacterial Other Antibiotics Infection Microorganisms Antibiotics Animal Husbandry Mammalian Cell Culture Anticancer Disease Research Fields

Target:

Environmental Pollutants Antibiotic Phospholipase Bacterial

Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both the nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. Neomycin sulfate inhibits IP3-mediated Ca ²⁺ release, MgATP-dependent Ca ²⁺ uptake, and electrical excitation-evoked skeletal muscle Ca ²⁺ transients. Neomycin sulfate depletes gut microbiota in specific mouse models, causes hearing impairment, and kidney damage with prolonged exposure. Neomycin sulfate can be used for the research of cancer .

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m-3M3FBS

10 Cited Publications

Cat. No.: HY-19619

CAS No.: 200933-14-8

Target:

Phospholipase Apoptosis

Research Areas:

Cancer

m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis .

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CCT129957

1 Cited Publications

Cat. No.: HY-111208

CAS No.: 883098-58-6

Purity: 99.71%

Target:

Phospholipase

Research Areas:

Cancer

CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC₅₀ of ~3 μM and a GC₅₀ of 15 μM. CCT129957 inhibits Ca ²⁺ release in squamous carcinoma cells at ~15 μM .

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