53 Results for "

PLPro

" in MedChemExpress (MCE) Product Catalog:
Products (53)

53 Results for "PLPro" in MCE Product Catalog:

16
6-Thioguanine
6-Thioguanine
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16 Publications Verification
Cat. No.: HY-13765
CAS No.: 154-42-7
Purity:  99.90%
Synonyms: Thioguanine; 2-Amino-6-purinethiol
Category:  

Infection Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology Cancer

Target:  

SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite

6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC50s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.
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16
GRL0617
GRL0617
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16 Publications Verification
Cat. No.: HY-117043
CAS No.: 1093070-16-6
Purity:  99.62%
Target:  

Deubiquitinase SARS-CoV

Research Areas:  

Infection

GRL0617 is a selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLpro), with an IC50 of 0.6 μM and a Ki value of 0.49 μM. GRL0617 also inhibits SARS-CoV with an EC50 of 14.5 μM. GRL0617 can be used for the research of severe acute respiratory syndrome .
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7
Acriflavine
Acriflavine
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7 Cited Publications
Cat. No.: HY-100575
CAS No.: 8048-52-0
Purity:  ≥98.0%
Synonyms: Acriflavinium chloride 3,6-Acridinediamine mix
Target:  

Fluorescent Dye Monocarboxylate Transporter Bacterial Fungal HIF/HIF Prolyl-Hydroxylase SARS-CoV

Research Areas:  

Infection Cancer

Acriflavine (Acriflavinium chloride) is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine is an antiseptic agent. Acriflavine is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2 .
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7
Acriflavine hydrochloride
Acriflavine hydrochloride
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7 Cited Publications
Cat. No.: HY-W088075
CAS No.: 69235-50-3
Synonyms: Acriflavinium chloride hydrochloride
Target:  

Fluorescent Dye HIF/HIF Prolyl-Hydroxylase Bacterial SARS-CoV Monocarboxylate Transporter Fungal

Research Areas:  

Infection Cancer

Acriflavine (Acriflavinium chloride) hydrochloride is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine hydrochloride is an antiseptic agent. Acriflavine hydrochloride is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine hydrochloride inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine hydrochloride is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine hydrochloride is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2 .
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6
PLpro inhibitor
PLpro inhibitor
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6 Cited Publications
Cat. No.: HY-17542
CAS No.: 1093070-14-4
Target:  

SARS-CoV

Research Areas:  

Infection

PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with an IC50 of 2.6 µM . PLpro inhibitor inhibits SARS-CoV-2 PLpro with an IC50 of 5.0 µM and an EC50 of 21.0 µM .
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4
4'-O-Methylbavachalcone
4'-O-Methylbavachalcone
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4 Cited Publications
Cat. No.: HY-N1910
CAS No.: 20784-60-5
Category:  

Infection Flavonoids Chalcones Phenols Polyphenols 500 - Internal Server Error | MedChemExpress

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