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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
PMNL
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "PMNL" in MCE Product Catalog:
2
Research Areas:
Quiflapon (MK-591) is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC50 of 1.6 nM in a FLAP binding assay. Quiflapon is also a potent and orally active Leukotriene biosynthesis (LT) inhibitor, shows IC50 values of 3.1 and 6.1 nM in intact human and elicited rat PMNLs, respectively. Quiflapon induces cell apoptosis .
1
1 Cited Publications
Target:
Research Areas:
15(S)-HETRE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid. It is an inhibitor of 5-LO in human PMNL with an IC50 value of 4.6 μM. In RBL cells, 15(S)-HETrE inhibits 5-LO, but is about 1/20 as potent as 15(S)-HpETE.
1
1 Cited Publications
Cat. No.: HY-P72507
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MMP8; PMNL Collagenase; Prev. CLG1; MMP-8; Matrix Metalloproteinase 8 (Neutrophil Collagenase); PMN Leukocyte Collagenase; Matrix Metalloproteinase-8; Collagenase 2; Neutrophil Collagenase; HNC; Matrix Metallopeptidase 8; PMNL-CL
Species:
Human
Source:
HEK293
Target:
Research Areas:
CJ-13,610, a nonredox-type 5-LO inhibitor, dose dependently suppresses 5-LO product formation in ionophore A23187-stimulated PMNL in the absence of exogenous AA with an IC50 of about 70 nM . PMNL: polymorphonuclear leukocytes; AA: arachidonic acid
Cat. No.: HY-113484
CAS No.: 80445-66-5
Synonyms: LTB5
Target:
Research Areas:
Leukotriene B5 (LTB5) is a leukotriene with diverse biological activities. It is a metabolite of eicosapentaenoic acid formed through the 5-lipoxygenase (5-LO) pathway. LTB5 increases contraction of bullfrog lung strips ex vivo in a concentration-dependent manner. In vivo, LTB5 (100 nM) reduces tumor volume in mice injected with Tm1 murine melanoma cells. LTB5 also elicits chemokinesis and lysosomal enzyme release from polymorphonuclear leukocytes (PMNLs) 20- to 30-fold less, and induces platelet aggregation 8-fold less, potently than LTB4.
Cat. No.: HY-N14970
CAS No.: 903574-41-4
Category:
Cat. No.: HY-10037R
CAS No.: 136668-42-3
Synonyms: MK-591 (Standard)
Target:
Research Areas:
Quiflapon (Standard) is the analytical standard of Quiflapon. This product is intended for research and analytical applications. Quiflapon (MK-591) is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC50?of 1.6 nM in a FLAP binding assay. Quiflapon is also a potent and orally active?Leukotriene biosynthesis (LT)?inhibitor, shows IC50?values of 3.1 and 6.1 nM in intact human and elicited rat PMNLs, respectively. Quiflapon induces cell apoptosis .
Cat. No.: HY-106200R
CAS No.: 179420-17-8
Target:
Research Areas:
CJ-13,610 (Standard) is the analytical standard of CJ-13,610 (HY-106200). This product is intended for research and analytical applications. CJ-13,610, a nonredox-type 5-LO inhibitor, dose dependently suppresses 5-LO product formation in ionophore A23187-stimulated PMNL in the absence of exogenous AA with an IC50 of about 70 nM . PMNL: polymorphonuclear leukocytes; AA: arachidonic acid
Cat. No.: HY-P73298
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MMP8; PMNL Collagenase; Prev. CLG1; MMP-8; Matrix Metalloproteinase 8 (Neutrophil Collagenase); PMN Leukocyte Collagenase; Matrix Metalloproteinase-8; Collagenase 2; Neutrophil Collagenase; HNC; Matrix Metallopeptidase 8; PMNL-CL
Species:
Human
Source:
HEK293
Cat. No.: HY-P73808
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MMP8; PMNL Collagenase; Prev. CLG1; MMP-8; Matrix Metalloproteinase 8 (Neutrophil Collagenase); PMN Leukocyte Collagenase; Matrix Metalloproteinase-8; Collagenase 2; Neutrophil Collagenase; HNC; Matrix Metallopeptidase 8; PMNL-CL
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P78328
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: MMP8; PMNL Collagenase; Prev. CLG1; MMP-8; Matrix Metalloproteinase 8 (Neutrophil Collagenase); PMN Leukocyte Collagenase; Matrix Metalloproteinase-8; Collagenase 2; Neutrophil Collagenase; HNC; Matrix Metallopeptidase 8; PMNL-CL
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P73809
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MMP8; PMNL Collagenase; Prev. CLG1; MMP-8; Matrix Metalloproteinase 8 (Neutrophil Collagenase); PMN Leukocyte Collagenase; Matrix Metalloproteinase-8; Collagenase 2; Neutrophil Collagenase; HNC; Matrix Metallopeptidase 8; PMNL-CL
Species:
Mouse
Source:
CHO
Cat. No.: HY-P700793
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MMP8; PMNL Collagenase; Prev. CLG1; MMP-8; Matrix Metalloproteinase 8 (Neutrophil Collagenase); PMN Leukocyte Collagenase; Matrix Metalloproteinase-8; Collagenase 2; Neutrophil Collagenase; HNC; Matrix Metallopeptidase 8; PMNL-CL
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P704792
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MMP8; PMNL Collagenase; Prev. CLG1; MMP-8; Matrix Metalloproteinase 8 (Neutrophil Collagenase); PMN Leukocyte Collagenase; Matrix Metalloproteinase-8; Collagenase 2; Neutrophil Collagenase; HNC; Matrix Metallopeptidase 8; PMNL-CL
Species:
Mouse
Source:
HEK293
Cat. No.: HY-19014
CAS No.: 83677-24-1
Target:
Research Areas:
KME-4 is an orally active dual inhibitor of 5-lipoxygenase (5-lipoxygenase) and cyclooxygenase (cyclooxygenase). KME-4 inhibits 5-lipoxygenase in the cytosol of guinea pig polymorphonuclear leukocytes (PMNL) and cyclooxygenase in rabbit platelets, with IC50 values of 0.85 μM and 0.44 μM, respectively. KME-4 can be used in studies related to arachidonic acid metabolism, inflammatory responses, and arthritis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
