8

dTRIM24

8 Publications Verification

Cat. No.: HY-111519

CAS No.: 2170695-14-2

Purity: 99.89%

Target:

PROTACs Epigenetic Reader Domain

Research Areas:

Cancer

dTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC, consists of ligands for von Hippel-Lindau and TRIM24.

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8

SPD304

8 Publications Verification

Cat. No.: HY-111255

CAS No.: 869998-49-2

Purity: 99.58%

Target:

TNF Receptor

Research Areas:

Cancer

SPD304 is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC₅₀ of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α .

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8

SPD304 dihydrochloride

8 Publications Verification

Cat. No.: HY-111255A

CAS No.: 1049741-03-8

Purity: 99.82%

Target:

TNF Receptor

Research Areas:

Inflammation/Immunology Cancer

SPD304 dihydrochloride is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC₅₀ of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α .

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5

BRD5529

5 Cited Publications

Cat. No.: HY-115497

CAS No.: 1358488-78-4

Purity: 98.94%

Target:

E1/E2/E3 Enzyme

Research Areas:

Infection Inflammation/Immunology

BRD5529 is an effective dose-dependent CARD9-TRIM62 protein–protein interaction (PPI) inhibitor with an IC₅₀ value of 8.6 μM. BRD5529 has potency and complete inhibition of CARD9 ubiquitinylation in vitro, also has favorable solubility. BRD5529 can be used for the research of inflammatory bowel disease (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC) .

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4

OF-1

4 Cited Publications

Cat. No.: HY-12518

CAS No.: 919973-83-4

Purity: 98.93%

Target:

Epigenetic Reader Domain

Research Areas:

Cancer

OF-1, a chemical probe, is a potent pan-BRPF bromodomain (BRD) inhibitor, with IC₅₀ values of 270 nM, 1.2 μM for TRIM24 and BRPF1B, respectively .

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3

UCB-9260

3 Cited Publications

Cat. No.: HY-133122

CAS No.: 1515888-53-5

Purity: 98.38%

Target:

TNF Receptor

Research Areas:

Inflammation/Immunology Cancer

UCB-9260, an orally active compound, inhibits TNF signaling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar K_d of 13 nM .

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2

Suc-AAPF-pNA

2 Cited Publications

Cat. No.: HY-P2573

CAS No.: 70967-97-4

Synonyms: Suc-Ala-Ala-Pro-Phe-PNA

Target:

Inhibitory Antibodies

Research Areas:

Others

Suc-AAPF-pNA (Suc-Ala-Ala-Pro-Phe-pNA) is a chromogenic p-nitroanilide (pNA) substrate with the K_m of 1.7 mM. Cleavage of Suc-AAPF-pNA releases 4-nitroaniline, which is yellow in colour and can be measured spectrophotometrically. Suc-AAPF-pNA can be used for the measurement of free and membrane-bound cathepsin G in human neutrophils .

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2

IACS-9571 hydrochloride

2 Cited Publications

Cat. No.: HY-102000B

CAS No.: 2319611-93-1

Purity: 99.85%

Synonyms: ASIS-P040 hydrochloride

Target:

Epigenetic Reader Domain

Research Areas:

Cancer

IACS-9571 (ASIS-P040) hydrochloride is a potent and selective inhibitor of TRIM24 and BRPF1, with an IC₅₀ of 8 nM for TRIM24, and K_ds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively .

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1

Suc-AAPA-pNA

1 Cited Publications

Cat. No.: HY-P4476

CAS No.: 72682-69-0

Target:

Ser/Thr Protease

Research Areas:

Others

Suc-AAPA-pNA is a substrate for chymotrypsin A and elastase. Suc-AAPA-pNA can be used for enzyme activity assay .

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1

Ac-DEVD-pNA

1 Cited Publications

Cat. No.: HY-P1006

CAS No.: 189950-66-1

Target:

Caspase

Research Areas:

Others

Ac-DEVD-pNA is a ligand for caspase-3/-7 and related cysteine proteases .

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1

Suc-Ala-Pro-pNA

1 Cited Publications

Cat. No.: HY-P4490

CAS No.: 95632-46-5

Target:

Prolyl Endopeptidase (PREP)

Research Areas:

Others

Suc-Ala-Pro-pNA is a peptide that serves as a substrate to detect the activity and stability of prolyl endopeptidase (PEP) .

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1

H-D-Phe-Pip-Arg-pNA

1 Cited Publications

Cat. No.: HY-123275

CAS No.: 64815-81-2

Synonyms: S-2238

Target:

Thrombin

Research Areas:

Others

H-D-Phe-Pip-Arg-pNA (S-2238) is a specific chromogenic peptide substrate for thrombin (Thrombin). The amide bond of H-D-Phe-Pip-Arg-pNA is rapidly hydrolyzed by thrombin, producing a characteristic yellow absorbance at 405 nm, and the change in absorbance is proportional to thrombin activity. H-D-Phe-Pip-Arg-pNA can be used in biochemical detection-related studies .

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1

H-D-Phe-Pip-Arg-pNA hydrochloride

1 Cited Publications

Cat. No.: HY-123275A

CAS No.: 160192-34-7

Purity: 99.40%

Synonyms: S-2238 hydrochloride

Target:

Thrombin

Research Areas:

Others

H-D-Phe-Pip-Arg-pNA hydrochloride (S-2238 hydrochloride) is a specific chromogenic peptide substrate for thrombin (Thrombin). The amide bond of H-D-Phe-Pip-Arg-pNA hydrochloride is rapidly hydrolyzed by thrombin, producing a characteristic yellow absorbance at 405 nm, and the change in absorbance is proportional to thrombin activity. H-D-Phe-Pip-Arg-pNA hydrochloride can be used in biochemical detection-related studies .

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1

H-D-Phe-Pip-Arg-pNA acetate

1 Cited Publications

Cat. No.: HY-123275B

CAS No.: 115388-96-0

Purity: 98.90%

Synonyms: S-2238 acetate

Target:

Thrombin

Research Areas:

Others

H-D-Phe-Pip-Arg-pNA acetate (S-2238 acetate) is a specific chromogenic peptide substrate for thrombin (Thrombin). The amide bond of H-D-Phe-Pip-Arg-pNA acetate is rapidly hydrolyzed by thrombin, producing a characteristic yellow absorbance at 405 nm, and the change in absorbance is proportional to thrombin activity. H-D-Phe-Pip-Arg-pNA acetate can be used in biochemical detection-related studies .

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