342 Results for "

PPAR-alpha

" in MedChemExpress (MCE) Product Catalog:
Products (342)

342 Results for "PPAR-alpha" in MCE Product Catalog:

232
GW9662
GW9662
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232 Publications Verification
Cat. No.: HY-16578
CAS No.: 22978-25-2
Target:  

PPAR

Research Areas:  

Cancer

GW9662 is a potent and selective PPARγ antagonist with an IC50 of 3.3 nM, showing 10 and 1000-fold selectivity over PPARα and PPARδ, respectively.
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156
Retinoic acid
Retinoic acid
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156 Cited Publications
Cat. No.: HY-14649
CAS No.: 302-79-4
Purity:  99.81%
Synonyms: Vitamin A acid; all-trans-Retinoic acid; ATRA
Category:  

Ketones, Aldehydes, Acids Whitening Agent Cosmetic Research Endogenous metabolite Disease Research Fields Cancer

Target:  

Organoid RAR/RXR PPAR Endogenous Metabolite Autophagy

Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.
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88
GW6471
GW6471
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88 Cited Publications
Cat. No.: HY-15372
CAS No.: 880635-03-0
Purity:  99.64%
Target:  

PPAR Apoptosis

Research Areas:  

Cancer

GW6471 is a selective peroxisome proliferator-activated receptor α (PPARα) antagonist. GW6471 reduces cancer stem cell viability, proliferation, and spheroid formation. GW6471 induces apoptosis and causes metabolic impairment including energy imbalance. GW6471 can be used for the research of paragangliomas and triple-negative breast cancer .
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68
SR-18292
SR-18292
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68 Cited Publications
Cat. No.: HY-101491
CAS No.: 2095432-55-4
Purity:  99.87%
Target:  

PGC-1α Autophagy

Research Areas:  

Metabolic Disease

SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes.
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40
Pirinixic acid
Pirinixic acid
0 Images
40 Cited Publications
Cat. No.: HY-16995
CAS No.: 50892-23-4
Synonyms: Wy-14643
Target:  

PPAR

Research Areas:  

Metabolic Disease Inflammation/Immunology Cancer

Pirinixic acid (Wy-14643) is a potent agonist of PPARα, with EC50s of 0.63 μM, 32 μM for murine PPARα and PPARγ, and 5.0 μM, 60 μM, 35 μM for human PPARα, PPARγ and PPARδ, respectively.
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36
Fenofibrate
Fenofibrate
0 Images
36 Cited Publications
Cat. No.: HY-17356
CAS No.: 49562-28-9
Target:  

PPAR Cytochrome P450 Autophagy

Research Areas:  

Cardiovascular Disease Cancer

Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.
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31
Icariin
Icariin
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31 Cited Publications
Cat. No.: HY-N0014
CAS No.: 489-32-7
Synonyms: Ieariline
Category:  

Cardiovascular Disease Flavonols Anti-aging Plants Flavonoids Monophenols Phenols 500 - Internal Server Error | MedChemExpress

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