8

W146

8 Publications Verification

Cat. No.: HY-101395

CAS No.: 909725-61-7

Purity: 99.83%

Target:

LPL Receptor Apoptosis

Research Areas:

Metabolic Disease Cancer

W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC₅₀ value of 398 nM.

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8

W146 TFA

8 Publications Verification

Cat. No.: HY-101395A

CAS No.: 909725-62-8

Purity: 98.22%

Target:

LPL Receptor Apoptosis

Research Areas:

Metabolic Disease Cancer

W146 TFA is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC₅₀ value of 398 nM.

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3

FTY720 (S)-Phosphate

3 Cited Publications

Cat. No.: HY-15382

CAS No.: 402616-26-6

Purity: 99.57%

Synonyms: (S)-FTY720P; (S)-FTY720 phosphate

Target:

LPL Receptor

Research Areas:

Inflammation/Immunology

FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

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2

Mocravimod

2 Cited Publications

Cat. No.: HY-109038

CAS No.: 509092-16-4

Synonyms: KRP-203 free base

Target:

LPL Receptor Reactive Oxygen Species (ROS) Mitochondrial Metabolism Akt GSK-3 JAK STAT

Research Areas:

Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer

Mocravimod (KRP-203 free base) is a sphingosine-1-phosphate receptor (S1PR) modulator that blocks the signal required by T cells to egress from lymph nodes and other lymphoid organs. Mocravimod preferentially binds to S1PR1 over S1PR2 and S1PR3 in cardiomyocytes. Mocravimod significantly lowered the concentration of reactive oxygen species (ROS), prevented mitochondrial permeability transition pore opening, boosted mitochondrial membrane potential (MMP), and increased phosphorylation of AKT, EKR, GSK-3β, JAK2, and STAT3. Mocravimod retains T cell effector function. Mocravimod can be used for the study of acute myelogenous leukemia, diabetes and Myocardial Ischemia-Reperfusion Injury (MIRI) ^[1] .

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2

Mocravimod hydrochloride

2 Cited Publications

Cat. No.: HY-13660

CAS No.: 509088-69-1

Purity: 99.68%

Synonyms: KRP-203

Target:

LPL Receptor Reactive Oxygen Species (ROS) Akt GSK-3 JAK STAT

Research Areas:

Metabolic Disease Inflammation/Immunology Cancer

Mocravimod (hydrochloride) is an orally active sphingosine-1-phosphate receptor (S1PR) modulator that blocks the signal required by T cells to egress from lymph nodes and other lymphoid organs. Mocravimod (hydrochloride) preferentially binds to S1PR1 over S1PR2 and S1PR3 in cardiomyocytes. Mocravimod (hydrochloride) significantly lowered the concentration of reactive oxygen species (ROS), prevented mitochondrial permeability transition pore opening, boosted mitochondrial membrane potential (MMP), and increased phosphorylation of AKT, EKR, GSK-3β, JAK2, and STAT3. Mocravimod (hydrochloride) retains T cell effector function. Mocravimod (hydrochloride) can be used for the study of acute myelogenous leukemia, diabetes and Myocardial Ischemia-Reperfusion Injury (MIRI) ^[1] .

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2

CYM-5520

2 Cited Publications

Cat. No.: HY-100953

CAS No.: 1449747-00-5

Purity: 99.48%

Target:

LPL Receptor

Research Areas:

Metabolic Disease

CYM-5520 is a selective and allosteric sphingosine 1-phosphate receptor 2 (S1PR2) agonist with an EC₅₀ of 480 nM. CYM-5520 does not activate S1PR1, S1PR3, S1PR4 and S1PR5 receptors. CYM-5520 can co-bind in the S1PR2 receptor with S1P. CYM-5520 can be used for osteoporosis research ^[1] .

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S1PR1 modulator 1

Cat. No.: HY-126145

CAS No.: 2328109-05-1

Purity: 99.52%

Target:

LPL Receptor

Research Areas:

Inflammation/Immunology

S1PR1 modulator 1 is a selective S1PR1 inhibitor, with a pIC₅₀ of 7.6, with >40- and >80-fold selectivity, over the other S1PR isoforms S1PR2/3/4 ^[1].

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RP101988

Cat. No.: HY-136578

CAS No.: 2990018-57-8

Purity: 98.80%

Target:

LPL Receptor Drug Metabolite

Research Areas:

Inflammation/Immunology Cancer

RP101988, the major active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC₅₀s of 0.19 nM and 32.8 nM for S1PR1 and S1PR5, respectivlely ^[1].

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Anti-TROP-2 Antibody (Pr1E11)

Cat. No.: HY-P990827

Anti-TROP-2 Antibody (Pr1E11) is a kind of mouse IgG1 κ chimeric antibody inhibitor, targeting to human TROP-2. Anti-TROP-2 Antibody (Pr1E11) specifically binds to TROP-2 with high affinity and shows low internalization activitv. Anti-TROP-2 Antibody (Pr1E11) can be used for the research of cancer, such as epithelial cancer and primary pancreatic cancer ^[1].

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KSI-6666

Cat. No.: HY-158417

CAS No.: 1807873-14-8

Target:

LPL Receptor

Research Areas:

Inflammation/Immunology

KSI-6666 is an orally active, competitive antagonist for sphingosine 1-phosphate receptor 1 (S1PR1), with an IC₅₀ of 6.4 nM. KSI-6666 exhibits anti-inflammatory efficacy in autoimmune encephalomyelitis model and T cell transfer colitis model ^[1].

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AtPep1

Cat. No.: HY-P10400

CAS No.: 902781-11-7

Target:

Phytohormone

Research Areas:

Infection

AtPep1 is an endogenous inducer of innate immune responses. AtPep1 can be isolated from Arabidopsis thaliana leaves. AtPep1 activates the transcription of defensin (PDF1.2), the expression of PROPEP1, the synthesis of hydrogen peroxide (H₂O₂) near leaf veins, and the alkalization of Arabidopsis suspension cell culture medium. AtPep1 induces the expression of genes encoding defensins and PR-1. AtPep1 is applicable to studies related to Pythium irregulare infection and pathogen infection ^[1] .

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S1PR1 Human Pre-designed siRNA Set A

Cat. No.: HY-RS12391

Target:

Small Interfering RNA (siRNA) LPL Receptor

Research Areas:

Others

S1PR1 Human Pre-designed siRNA Set A contains three designed siRNAs for S1PR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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S1PR1 agonist 3

Cat. No.: HY-178491

CAS No.: 3028594-26-2

Target:

LPL Receptor

Research Areas:

Inflammation/Immunology

S1PR1 agonist 3 (Compound Y18) is a highly selective S1PR1 receptor agonist (EC₅₀=0.98 nM). S1PR1 agonist 3 is promising for research of autoimmune diseases such as multiple sclerosis and ulcerative colitis ^[1].

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AtPep1 TFA

Cat. No.: HY-P10400A

Target:

Phytohormone

Research Areas:

Infection

AtPep1 TFA is an endogenous inducer of innate immune responses. AtPep1 TFA can be isolated from Arabidopsis thaliana leaves. AtPep1 TFA activates the transcription of defensin (PDF1.2), the expression of PROPEP1, the synthesis of hydrogen peroxide (H₂O₂) near leaf veins, and the alkalization of Arabidopsis suspension cell culture medium. AtPep1 TFA induces the expression of genes encoding defensins and PR-1. AtPep1 TFA is applicable to studies related to Pythium irregulare infection and pathogen infection ^[1] .

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S1PR1 agonist 2

Cat. No.: HY-143865

CAS No.: 2695535-01-2

Target:

LPL Receptor

Research Areas:

Inflammation/Immunology

S1PR1 agonist 2 is a potent agonist of S1PR1. Sphingosine-1-phosphate (S1P) is a cell membrane-derived lysophospholipid signalling molecule that exerts its physiological functions mainly by stimulating some members of the G protein-coupled receptor family. S1PR1 agonist 2 has the potential for the research of autoimmune diseases (extracted from patent WO2021175225A1, compound 1) ^[1].

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(S)-FTY720-phosphonate

Cat. No.: HY-15382A

CAS No.: 1142015-10-8

Purity: 99.91%

Target:

LPL Receptor

Research Areas:

Inflammation/Immunology

FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

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Vonifimod

Cat. No.: HY-148805

CAS No.: 2118903-18-5

Synonyms: SLB736 free acid

Target:

LPL Receptor

Research Areas:

Inflammation/Immunology

Vonifimod (SLB736 free acid) is an immunomodulator that targets S1PR1 and S1PR4, which can be used in the research of autoimmune diseases ^[1].

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Fingolimod hydrochloride (Standard)

Cat. No.: HY-12005R

CAS No.: 162359-56-0

Synonyms: FTY720 (Standard)

Target:

Reference Standards LPL Receptor PAK

Research Areas:

Inflammation/Immunology Cancer

Fingolimod (hydrochloride) (Standard) is the analytical standard of Fingolimod (hydrochloride). This product is intended for research and analytical applications. Fingolimod hydrochloride (FTY720), an analog of sphingosine, is a potent sphingosine 1-phosphate (S1P) receptors modulator. Fingolimod hydrochloride is phosphorylated by sphingosine kinases, particularly by SK2, and then binds S1PR1, 3, 4, and 5. Fingolimod hydrochloride induces the internalization of S1P1, and consequently, inhibits S1P activity. Fingolimod hydrochloride also is a pak1 activator ^[1] .

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S1PR1 ligand 1

Cat. No.: HY-149210

CAS No.: 2845249-11-6

Target:

LPL Receptor

Research Areas:

Others

S1PR1 ligand 1 (compound 6 h) is a specific S1PR1 ligand with IC₅₀ = 8.7 nM. S1PR1 ligand 1 has good brain uptake. S1PR1 ligand 1 can be labeled with ¹⁸F to study the function of S1PR1 in brain diseases ^[1].

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3-Acetonyl-3-hydroxyoxindole

Cat. No.: HY-N1836

CAS No.: 33417-17-3

Synonyms: 3-Hydroxy-3-acetonyloxindole

Category:

Infection Acanthaceae Extract Alkaloids Plants Disease Research Fields 500 - Internal Server Error | MedChemExpress

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