225 Results for "

PS

" in MedChemExpress (MCE) Product Catalog:
Products (225)

225 Results for "PS" in MCE Product Catalog:

286
Bortezomib
Bortezomib
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286 Publications Verification
Cat. No.: HY-10227
CAS No.: 179324-69-7
Purity:  99.91%
Synonyms: PS-341; LDP-341; NSC 681239
Target:  

Proteasome NF-κB Apoptosis Autophagy TREM receptor Ligands for Target Protein for PROTAC

Research Areas:  

Cancer

Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM) . Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs) .
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95
2’3’-c-di-AM(PS)2 (Rp,Rp)
2’3’-c-di-AM(PS)2 (Rp,Rp)
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95 Cited Publications
Cat. No.: HY-12885
CAS No.: 1638241-89-0
Purity:  99.40%
Synonyms: ADU-S100; MIW815; ML RR-S2 CDA
Target:  

STING

Research Areas:  

Inflammation/Immunology Cancer

2’3’-c-di-AM(PS)2 (Rp,Rp) (ADU-S100), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity .
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95
2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt
2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt
0 Images
95 Cited Publications
Cat. No.: HY-12885A
CAS No.: 1638750-95-4
Purity:  99.43%
Synonyms: ADU-S100 disodium salt; MIW815 disodium salt; ML RR-S2 CDA disodium salt
Target:  

STING

Research Areas:  

Inflammation/Immunology Cancer

2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt (ADU-S100 disodium salt) is an activator of stimulator of interferon genes (STING).
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95
2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
0 Images
95 Cited Publications
Cat. No.: HY-12885B
CAS No.: 1638750-96-5
Purity:  99.60%
Synonyms: ADU-S100 ammonium salt; MIW815 ammonium salt; ML RR-S2 CDA ammonium salt
Target:  

STING

Research Areas:  

Inflammation/Immunology Cancer

2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt (ADU-S100 ammonium salt), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity .
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11
Onalespib
Onalespib
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11 Cited Publications
Cat. No.: HY-14463
CAS No.: 912999-49-6
Purity:  99.92%
Synonyms: AT13387
Target:  

HSP

Research Areas:  

Cancer

Onalespib (AT13387) is a potent and cross the blood-brain barrier heat-shock-protein-90 (Hsp90) inhibitor. Onalespib inhibits the proliferation, survival and migration. Onalespib decreases the expression of EGFR, p-EGFR, AKT, P-AKT, ERK1/2, P-ERK1/2, S6, P-S6 protein. Onalespib shows antitumor activity. Onalespib has the potential for the research of non-small cell lung cancer (NSCLC) .
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11
Beta Actin Antibody (YA823)
Beta Actin Antibody (YA823)
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11 Cited Publications
Cat. No.: HY-P80438
Synonyms: A26C1A antibody; A26C1B antibody; ACTB antibody; ACTB_HUMAN antibody; Actin beta antibody; Actin cytoplasmic 1 antibody; Actin, cytoplasmic 1, N-terminally processed antibody; Actx antibody; b actin antibody; Beta cytoskeletal actin antibody; Beta-actin antibody; BRWS1 antibody; E430023M04Rik antibody; MGC128179 antibody; PS1TP5 binding protein 1 antibody; PS1TP5BP1 antibody; β-actin antibody

Host:  

Mouse

Application:  

WB, IHC-P, ICC/IF

Reactivity:  

Human, Mouse, Rat

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9
RMC-5552
RMC-5552
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9 Cited Publications
Cat. No.: HY-132168
CAS No.: 2382768-62-7
Purity:  99.94%
Target:  

mTOR

Research Areas:  

Cancer

RMC-5552 is a potent and selective mTORC1 inhibitor. RMC-5552 inhibits phosphorylation of mTORC1 pS6K and p4EBP1 with IC50s of 0.14 nM and 0.48 nM, respectively. RMC-5552 shows much lower pAKT inhibition (IC50 of 19 nM), resulting in mTORC1/mTORC2 selectivity approaching 40-fold. RMC-5552 has anti-cancer activity .
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8
CA77.1
CA77.1
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8 Cited Publications
Cat. No.: HY-134923
CAS No.: 2412270-22-3
Purity:  99.98%
Target:  

Autophagy

Research Areas:  

Neurological Disease

CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 is a derivative of AR7 (HY-101106) and can increase the expression of the lysosomal receptor LAMP2A in?lysosomes. CA77.1 improves behavior and neuropathology in PS19 mice model and can be used for alzheimer's?disease research .
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6
PS10
PS10
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6 Cited Publications
Cat. No.: HY-121744
CAS No.: 1564265-82-2
Purity:  98.51%
Target:  

PDHK

Research Areas:  

Inflammation/Immunology

PS10 is a novel, potent and ATP-competitive pan-PDK inhibitor, inhibits all PDK isoforms with IC50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affinity for PDK2 (Kd= 239 nM) than for Hsp90 (Kd= 47 μM) . PS10 improves glucose tolerance, stimulates myocardial carbohydrate oxidation in diet-induced obesity. PS10 has the potential for the investigation of diabetic cardiomyopathy .PDK: pyruvate dehydrogenase kinase
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5
PS-1145
PS-1145
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5 Cited Publications
Cat. No.: HY-18008
CAS No.: 431898-65-6
Target:  

IKK Apoptosis

Research Areas:  

Cancer

PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM.
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5
PS48
PS48
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5 Cited Publications
Cat. No.: HY-15967
CAS No.: 1180676-32-7
Target:  

PDK-1

Research Areas:  

Cancer

PS48 is an activator of PDK1 with an AC50 of 8 μM.
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3
Rheb inhibitor NR1
Rheb inhibitor NR1
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3 Cited Publications
Cat. No.: HY-124798
CAS No.: 2216763-38-9
Purity:  99.26%
Target:  

mTOR

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

Rheb inhibitor NR1 is a Rheb inhibitor with an IC50 of 2.1 µM in the Rheb-IVK assay. Rheb inhibitor NR1 can directly bind Rheb in the switch II domain and selectively inhibit the activation of mechanistic target of rapamycin complex 1 (mTORC1). Rheb inhibitor NR1 inhibits the phosphorylation of mTORC1 driven T389pS6K1 and increases the phosphorylation of S473pAKT in a dose-dependent manner. Rheb inhibitor NR1 does not influence mTORC2 activity .
(Rheb-IVK: Rheb-dependent mTORC1 kinase activity)
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2
PS372424 hydrochloride
PS372424 hydrochloride
0 Images
2 Cited Publications
Cat. No.: HY-111149A
CAS No.: 1596362-29-6
Purity:  95.03%
Target:  

CXCR

Research Areas:  

Inflammation/Immunology

PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammation .
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2
Bavituximab
Bavituximab
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2 Cited Publications
Cat. No.: HY-P99279
CAS No.: 648904-28-3
Synonyms: Anti-Human Phosphatidylserine Recombinant Antibody; PGN-401; CH3G4

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) is a phosphatidylserine (PS)-targeting monoclonal antibody, suppresses tumor growth by targeting tumor vasculature and reactivating antitumor immunity. Bavituximab plus Paclitaxel (HY-B0015) and Carboplatin (HY-17393), have enhanced inhibition on non-small-cell lung cancer .
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2
3′,6-Disinapoylsucrose
3′,6-Disinapoylsucrose
0 Images
2 Cited Publications
Cat. No.: HY-N1414A
CAS No.: 76656-80-9
Category:  

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