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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
PSB172656
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "PSB172656" in MCE Product Catalog:
Cat. No.: HY-176446
CAS No.: 2641397-91-1
Research Areas:
PSB-172656 is a selective MRGPRX2 antagonist with a Ki of 0.142 nM. PSB-172656 competitively blocks receptor activation by multiple agonists, inhibits Gαq/Gαi dissociation and β-arrestin recruitment, and blocks CXCL14-induced MRGPRX2 calcium mobilization and MRGPRB2 activation. PSB-172656 blocks signaling of the mouse ortholog and mast cell activation, and prevents agonist-induced tracheal contraction, hind paw edema, and systemic anaphylactic symptoms. PSB-172656 can be used for research on mast cell-mediated hypersensitivity and chronic inflammatory diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
