Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
PY-Alo
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "PY-Alo" in MCE Product Catalog:
Cat. No.: HY-189656
Target:
Apoptosis Autophagy Reactive Oxygen Species (ROS) MMP Bcl-2 Family Caspase p62 Atg8/LC3 MDM-2/p53
Research Areas:
PY-Alo is a DNA intercalator with a Ka of 3.46 × 10 5 M −1. PY-Alo induces DNA damage through backbone intercalation and non-covalent hydrogen bonding, downregulates the transcription of key genes in mitochondrial oxidative phosphorylation, and disrupts mitochondrial homeostasis, thereby synergistically inducing apoptosis (apoptosis) and autophagy (autophagy) in cells. PY-Alo exhibits cytotoxicity against both wild-type and Cisplatin (HY-17394)-resistant ovarian cancer cells. PY-Alo can be used for research on ovarian cancer .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
