Partial agonist | MedChemExpress (MCE) Life Science Reagents

Infection Neurological Disease Inflammation/Immunology

Research Areas:

Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole can be used for the research of schizophrenia and COVID19 .

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Aripiprazole monohydrate

11 Cited Publications

Cat. No.: HY-14546A

CAS No.: 851220-85-4

Synonyms: OPC-14597 monohydrate

Target:

Infection Neurological Disease Inflammation/Immunology

Research Areas:

Aripiprazole (OPC-14597) monohydrate, an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole monohydrate is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole monohydrate can be used for the research of schizophrenia and COVID19 .

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11

Vortioxetine

11 Cited Publications

Cat. No.: HY-15414

CAS No.: 508233-74-7

Purity: 98.61%

Synonyms: Lu AA 21004

Target:

Infection Neurological Disease Cancer

Research Areas:

Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of serotonin transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial agonist of 5-HT_1B (K_i: 15 nM, 33 nM) .

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Aripiprazole-d8-1

11 Cited Publications

Cat. No.: HY-14546S1

CAS No.: 1089115-04-7

Synonyms: OPC-14597-d₈

Aripiprazole (1,1,2,2,3,3,4,4-d₈) is the deuterium labeled Aripiprazole. Aripiprazole (OPC-14597) is a human 5-HT1A receptor partial agonist with a K_i of 4.2 nM .

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Vortioxetine hydrobromide

11 Cited Publications

Cat. No.: HY-15414A

CAS No.: 960203-27-4

Purity: 99.87%

Synonyms: Lu AA21004 hydrobromide

Target:

Neurological Disease Cancer

Research Areas:

Vortioxetine (Lu AA 21004) hydrobromide is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial 5-HT_1B agonist (K_i: 15 nM, 33 nM) .

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11

Lurasidone Hydrochloride

11 Cited Publications

Cat. No.: HY-B0032

CAS No.: 367514-88-3

Synonyms: SM-13496 Hydrochloride

Target:

Research Areas:

Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D₂ and 5-HT₇ with IC₅₀s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT_1A receptor with an IC₅₀ of 6.75 nM.

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11

Lurasidone

11 Cited Publications

Cat. No.: HY-B0032A

CAS No.: 367514-87-2

Synonyms: SM-13496

Target:

Research Areas:

Alkaloids Aporphine Alkaloids Plants Other Families Extract Isoquinoline Alkaloids

Lurasidone (SM-13496) is an antagonist of both dopamine D₂ and 5-HT₇ with IC₅₀s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496) is also a partial agonist of 5-HT_1A receptor with an IC₅₀ of 6.75 nM.

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9

Nuciferine

9 Cited Publications

Cat. No.: HY-N0049

CAS No.: 475-83-2

Category:

Target:

Parasite 5-HT Receptor Dopamine Receptor

Nuciferine is an antagonist at 5-HT_2A (IC₅₀=478 nM), 5-HT_2C (IC₅₀=131 nM), and 5-HT_2B (IC₅₀=1 μM), an inverse agonist at 5-HT₇ (IC₅₀=150 nM), a partial agonist at D₂ (EC₅₀=64 nM), D₅ (EC₅₀=2.6 μM) and 5-HT₆ (EC₅₀=700 nM), an agonist at 5-HT_1A (EC₅₀=3.2 μM) and D₄ (EC₅₀=2 μM) receptor.

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8

Vilazodone Hydrochloride

8 Cited Publications

Cat. No.: HY-14261

CAS No.: 163521-08-2

Purity: 100.70%

Synonyms: EMD 68843 Hydrochloride; SB659746A Hydrochloride

Target:

Research Areas:

Microorganisms Antibiotics Resistance Selection Disease Research Antibacterial Other Antibiotics

Vilazodone Hydrochloride (EMD 68843 Hydrochloride) is a serotonin transporter (SER) inhibitor and 5-HT_1A receptor partial agonist.

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8

D-Cycloserine

8 Cited Publications

Cat. No.: HY-B0030

CAS No.: 68-41-7

Category:

Target:

iGluR Bacterial Antibiotic

D-Cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes, with blood-brain barrier permeability. D-Cycloserine is a partial NMDA agonist that can improve cognitive functions. D-Cycloserine can be used for multidrug-resistant tuberculosis research .

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Vilazodone

8 Cited Publications

Cat. No.: HY-14262

CAS No.: 163521-12-8

Purity: 99.84%

Synonyms: EMD 68843; SB659746A

Target:

Research Areas: