178 Results for "

Permeability enhancer

" in MedChemExpress (MCE) Product Catalog:
Products (178)

178 Results for "Permeability enhancer" in MCE Product Catalog:

54
Methyllycaconitine citrate
Methyllycaconitine citrate
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54 Publications Verification
Cat. No.: HY-N2332A
CAS No.: 351344-10-0
Synonyms: MLA citrate
Target:  

nAChR Autophagy Reactive Oxygen Species (ROS) mTOR

Research Areas:  

Neurological Disease

Methyllycaconitine (MLA) citrate is a blood-brain barrier-permeable antagonist of α7 nicotinic acetylcholine receptor (α7nAChR) with an IC50 of 2 nM. Methyllycaconitine citrate inhibits Aβ25-35-induced autophagy by restoring the mTOR pathway, and prevents reactive oxygen species (ROS) production, microglial activation, reduced dopamine uptake, loss of dopaminergic terminals and catecholamine secretion. Methyllycaconitine citrate induces hippocampal glutamate efflux, enhances long-term potentiation, and improves memory acquisition. Methyllycaconitine citrate can be used in research related to Alzheimer's disease, cerebral palsy, Parkinson's disease and schizophrenia .
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29
Solutol HS-15
Solutol HS-15
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29 Cited Publications
Cat. No.: HY-Y1893
CAS No.: 61909-81-7
Synonyms: Polyethylene glycol 12-hydroxystearate
Target:  

Biochemical Assay Reagents

Research Areas:  

Others

Solutol HS-15, a Macrogol 15 hydroxy stearate, is a permeability enhancer .
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20
Rolipram
Rolipram
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20 Cited Publications
Cat. No.: HY-16900
CAS No.: 61413-54-5
Synonyms: (R,S)-Rolipram; (±)-Rolipram; ZK 62711
Target:  

Bacterial HIV Phosphodiesterase (PDE) Epigenetic Reader Domain Amyloid-β

Research Areas:  

Infection Neurological Disease Cancer

Rolipram is a PDE4 inhibitor, with blood-brain barrier permeability, that reverses β-amyloid-induced learning and memory impairment in rats. Rolipram elevates intracellular cAMP and clevels and regulates the cAMP/CREB signaling pathway, thereby alleviating neuroinflammation and apoptotic responses. Rolipram promotes neuronal differentiation of human bone marrow mesenchymal stem cells and inhibits Methamphetamine- and morphine-induced hyperlocomotion in mice. Rolipram also reduces the viability of glioblastoma stem-like cells and enhances Bevacizumab (HY-P9906)-induced cell death. Rolipram inhibits the expression of proinflammatory cytokines and enhances central noradrenergic transmission. Rolipram is mainly used in studies related to various central nervous system diseases including Alzheimer's disease, major depressive disorder, glioblastoma multiforme, and multiple sclerosis .
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14
N-Acetyl-L-cysteine ethyl ester
N-Acetyl-L-cysteine ethyl ester
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14 Cited Publications
Cat. No.: HY-134495
CAS No.: 59587-09-6
Purity:  98.26%
Synonyms: N-Acetylcysteine ethyl ester; NACET
Target:  

Reactive Oxygen Species (ROS)

Research Areas:  

Metabolic Disease

N-Acetyl-L-cysteine ethyl ester is an esterified form of N-acetyl-L-cysteine (NAC). N-Acetyl-L-cysteine ethyl ester exhibits enhanced cell permeability, and produce NAC and cysteine. N-Acetyl-L-cysteine ethyl ester increases circulating hydrogen sulfide (H2S) and can be used as an H2S producer. N-Acetyl-L-cysteine ethyl ester has the potential to substitute NAC as a mucolytic agent, and as a GSH-related antioxidant .
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11
Ligustrazine
Ligustrazine
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11 Cited Publications
Cat. No.: HY-N0264
CAS No.: 1124-11-4
Synonyms: Chuanxiongzine; Tetramethylpyrazine
Category:  

Cardiovascular Disease Natural Products Neurological Disease 500 - Internal Server Error | MedChemExpress

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