2 Results for "

Petasin

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Petasin" in MCE Product Catalog:

Petasin
Petasin
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Cat. No.: HY-N10612
CAS No.: 26577-85-5
Category:  

Natural Products Plants Compositae Extract Piptadenia Benth.

Target:  

Mitochondrial Metabolism AMPK

Petasin is an orally active, potent inhibitor of mitochondrial electron transport chain complex I (ETCC1) with an IC50 of 3.55 μM. Petasin functionally activates AMPK by inhibiting mitochondrial respiration and increasing the intracellular AMP/ATP ratio. Petasin inhibits leukotriene production and eosinophil effector responses, as well as tumor cell proliferation, migration, invasion, and in vivo tumor growth and metastasis. Petasin is also a natural sesquiterpene ester that can be found in plants of the Petasites genus, such as Petasites japonicus and Petasites hybridus. Petasin can be used in studies related to cancer metabolism, glucose and lipid metabolism, and inflammation .
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S-Petasin
S-Petasin
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Cat. No.: HY-N17617
CAS No.: 70238-51-6
Category:  

Natural Products Plants Compositae Extract Petasites hybridus (L.) G.Gaertn., B.Mey. & Schreb.

Target:  

Phosphodiesterase (PDE) Apoptosis NO Synthase Caspase PPAR Bcl-2 Family PARP

S-Petasin is a phosphodiesterase (PDE) inhibitor with IC50 values of 25.5 μM and 17.5 μM for PDE3 and PDE4, respectively. S-Petasin inhibits cholesterol side-chain cleavage enzyme, 11β-hydroxylase, PPAR-γ, and iNOS induction at RNA and protein levels. S-Petasin induces apoptosis, activates caspases, cleaves PARP, modulates mitochondrial membrane permeability, and regulates BCL2/BAX, p53, Bcl-XL, MMP-2, MMP-9, p21, CDK4, and cyclin D1 expression. S-Petasin reduces inflammatory cell accumulation, cytokine and IgE levels, and enhances serum IgG2a levels. S-Petasin relaxes isolated sensitized guinea pig trachealis and exhibits gastrointestinal anti-spasmodic activity. S-Petasin reduces tonsillitis severity and asthmatic attack frequency. S-Petasin can be used for the research of prostate cancer, obesity, melanoma, allergic asthma, asthma, and peritonitis .
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