7

Vasopressin

7 Cited Publications

Cat. No.: HY-B1811

CAS No.: 11000-17-2

Synonyms: Arginine vasopressin; Antidiuretic hormone

Category:

Neurological Disease Cyclopeptides Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis, and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of corticotropin releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors .

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6

Mitotane

6 Cited Publications

Cat. No.: HY-13690

CAS No.: 53-19-0

Purity: 99.92%

Synonyms: 2,4′-DDD; o,p'-DDD

Target:

Apoptosis

Research Areas:

Cancer

Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .

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5

PACAP (1-38), human, ovine, rat

5 Cited Publications

Cat. No.: HY-P0221

CAS No.: 137061-48-4

Synonyms: Pituitary Adenylate Cyclase Activating Polypeptide 38

Target:

PACAP Receptor ERK EGFR Reactive Oxygen Species (ROS) Calcium Channel

Research Areas:

Infection Neurological Disease

PACAP (1-38), human, ovine, rat is a PAC₁ receptor agonist. PACAP (1-38), human, ovine, rat binds to PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 with IC₅₀s of 4 nM, 2 nM, and 1 nM, respectively. PACAP (1-38), human, ovine, rat increases the α-secretase activity. PACAP (1-38), human, ovine, rat elevates cytosolic Ca ²⁺, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP (1-38), human, ovine, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP (1-38), human, ovine, rat can be used for neurotrophic and neuroprotective research .

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5

FSH Protein, Human (HEK293, Fc)

5 Cited Publications

Cat. No.: HY-P74133

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: CGA; Anterior Pituitary Glycoprotein Hormones Common Subunit Alpha; Glycoprotein Hormones, Alpha Polypeptide; Follicle-Stimulating Hormone Alpha Subunit; Glycoprotein Hormones Alpha Chain; Chorionic Gonadotropin, Alpha Polypeptide; GPA1; Follicle-Stimulat

Species:

Human

Source:

HEK293

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5

Ibutamoren

5 Cited Publications

Cat. No.: HY-10199A

CAS No.: 159634-47-6

Purity: 98.52%

Synonyms: MK-677 free base; MK-0677 free base

Target:

GHSR Insulin Receptor

Research Areas:

Neurological Disease Metabolic Disease

Ibutamoren (MK-677 free base; MK-0677 free base) is an orally active non-peptide growth hormone secretagogue receptor agonist. Ibutamoren activates signal cascades by mimicking endogenous ligands, triggers pulsatile release of growth hormone from the pituitary gland, and increases serum levels of IGF-1 and insulin-like growth factor-binding protein 3. Ibutamoren not only increases the frequency of growth hormone pulses in male individuals, but also promotes elevated bone formation markers in female individuals with postmenopausal osteoporosis. The combination of Ibutamoren with Alendronate sodium hydrate (HY-11101) significantly increases bone mineral density at the femoral neck. However, Ibutamoren may cause mild, reversible adverse reactions such as increased appetite, fluid retention, and elevated fasting blood glucose. Ibutamoren has been widely used in studies related to idiopathic growth hormone deficiency, sarcopenia, Alzheimer's disease, and osteoporosis .

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3

Chorionic gonadotrophin

3 Cited Publications

Cat. No.: HY-107953

CAS No.: 9002-61-3

Synonyms: hCG; Chorionic gonadotropic hormone

Category:

Natural Products Endogenous metabolite Disease Research Fields Endocrinology

Target:

GnRH Receptor

Chorionic gonadotrophin (hCG) is a gonadotropin that can be isolated from the anterior pituitary gland. Chorionic gonadotrophin has potential applications in ovarian and follicular development .

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3

Corticotropin-releasing factor (human)

3 Cited Publications

Cat. No.: HY-P0086

CAS No.: 86784-80-7

Synonyms: Human CRF; Human corticotropin-releasing factor

Target:

CRFR

Research Areas:

Neurological Disease

Corticotropin-releasing factor human (Human CRF) stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary.

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2

Tiratricol

2 Cited Publications

Cat. No.: HY-B1201

CAS No.: 51-24-1

Synonyms: 3,3',5-Triiodothyroacetic acid

Target:

Flavivirus Thyroid Hormone Receptor TNF Receptor

Research Areas:

Endocrinology

Tiratricol is an orally available thyroid hormone analog that inhibits pituitary thyroid-stimulating hormone secretion. Tiratricol is an intracellular toxin neutralizer that inhibits LPS and lipid A cytotoxicity with IC₅₀s of 20 μM and 32 μM, respectively. Tiratricol reduces TNF production in lipopolysaccharide-stimulated macrophages. Tiratricol also has antiviral activity and is an inhibitor of yellow fever virus (Flavivirus). It can bind to the RdRp domain of the viral NS5 protein to hinder YFV replication. .

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2

(R)-Nimodipine

2 Cited Publications

Cat. No.: HY-B0265A

CAS No.: 77940-92-2

Synonyms: (R)-BAY-e 9736

Target:

Calcium Channel

Research Areas:

Cardiovascular Disease Neurological Disease

(R)-Nimodipine ((R)-BAY-e 9736) is an orally active, blood-brain barrier-permeable L-type calcium channel blocker with an IC₅₀ of 5 nM. (R)-Nimodipine inhibits corticosterone release by blocking calcium channels on the hypothalamic-pituitary-adrenal axis, thereby reversing immobilization stress-induced memory impairment and behavioral abnormalities. (R)-Nimodipine is widely used in studies related to aneurysmal subarachnoid hemorrhage, cerebral ischemia, epilepsy, age-related degenerative neurological diseases, and alcohol intoxication .

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2

Serum thymic factor

2 Cited Publications

Cat. No.: HY-P3206

CAS No.: 63958-90-7

Synonyms: Thymulin; Thymic factor

Target:

ERK

Research Areas:

Neurological Disease Inflammation/Immunology Endocrinology

Serum thymic factor (Thymulin) is a zinc-dependent immunomodulatory peptide hormone, which can be produced by the thymic epithelial cells. Serum thymic factor stimulates the release of hormones from the pituitary gland, exhibits hypophysiotropic activity. Serum thymic factor protects rats from Cephaloridine (HY-B2072)-induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor exhibits anti-diabetic, anti-inflammatory and analgesic effects. Serum thymic factor can be used in research about endocrine, reproductive, neurodegenerative and inflammatory diseases .

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2

Serum thymic factor acetate

2 Cited Publications

Cat. No.: HY-P3206A

CAS No.: 125117-65-9

Synonyms: Thymulin acetate; Thymic factor acetate

Target:

ERK

Research Areas:

Neurological Disease Inflammation/Immunology Endocrinology

Serum thymic factor acetate (Thymulin acetate) is the acetate salt form of Serum thymic factor (HY-P3206). Serum thymic factor acetate is a zinc-dependent immunomodulatory peptide hormone, which can be produced by the thymic epithelial cells. Serum thymic factor acetate stimulates the release of hormones from the pituitary gland, exhibits hypophysiotropic activity. Serum thymic factor acetate protects rats from Cephaloridine (HY-B2072)-induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor acetate exhibits anti-diabetic, anti-inflammatory and analgesic effects. Serum thymic factor acetate can be used in research about endocrine, reproductive, neurodegenerative and inflammatory diseases .

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2

McN-A-343

2 Cited Publications

Cat. No.: HY-107648

CAS No.: 55-45-8

Purity: 99.81%

Target:

mAChR

Research Areas:

Neurological Disease Inflammation/Immunology

McN-A-343 is a selective M1 muscarinic agonist that stimulates muscarinic transmission in sympathetic ganglia. McN-A-343 produces a significant inhibitory effect on Muscarine (HY-121404)-evoked catecholamine secretion from the isolated perfused rat adrenal gland. McN-A-343 is involved in the regulation of neuronal firing and activates enteroendocrine L cells to release glucagon-like peptide 1 (GLP-1) and modulates the secretion of α-melanocyte stimulating hormone (α-MSH) from the pituitary gland in the central nervous system. McN-A-343 reduces colonic inflammation and oxidative stress in Acetic acid (HY-Y0319)-induced ulcerative colitis (UC) mice. McN-A-343 can be used for the study of ulcerative colitis .

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2

GH/Somatotropin Protein, Mouse

2 Cited Publications

Cat. No.: HY-P70261

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: GH1; Growth Hormone 1 Variant 2; Growth Hormone 1; Growth Hormone 1 Variant 1; GH-N; Growth Hormone 1 Isoform 1; GH; HCG1749481, Isoform CRA_aa; Pituitary Growth Hormone; Growth Hormone 1 Isoform 2; Somatotropin; HCG1749481, Isoform CRA_s; HGH-N; HCG1749481, Isoform CRA_g; GHN; Growth Hormone; Growth Hormone B5; IGHD1A; GHB5; IGHD1B; HGH; IGHD2

Species:

Mouse

Source:

E. coli

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