CAS No.: 2030241-59-7

Purity: 99.84%

Target:

Research Areas:

TAM-16 is a potent and orally active polyketide synthase 13 (Pks13) inhibitor with an IC₅₀ value of 0.32 μM. TAM-16 has promising activity against Mycobacterium tuberculosis. TAM-16 inhibits hERG cardiac ion channel .

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Thiophene-2

Cat. No.: HY-117145

CAS No.: 420089-51-6

Purity: 99.90%

Target:

Bacterial

Research Areas:

Infection

Thiophene-2 (TP2) is a specific polyketide synthase 13 (Pks13) inhibitor. Thiophene-2 inhibits mycolic acid biosynthesis and rapidly leads to mycobacterial cell death. Thiophene-2 is active against Mycobacterium tuberculosis with a MIC value of 1 μM, and has potent anti-tuberculosis activity .

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Pks13-IN-2

Cat. No.: HY-168956

Target:

Bacterial

Research Areas:

Infection

Pks13-IN-2 (Compound 43) is an orally active inhibitor of Pks13. Pks13-IN-2 exhibits inhibitory activity against Mycobacterium tuberculosis H37Rv, with a MIC of 0.8-1.8 μM. Pks13-IN-2 shows good metabolic stability in mouse liver microsomes and hepatocytes. Pks13-IN-2 can be used for tuberculosis research .

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Pks13-TE inhibitor 2

Cat. No.: HY-151598

CAS No.: 3031462-75-3

Target:

Bacterial

Research Areas:

Infection

Pks13-TE inhibitor 2 (compound 32) is a 13-Thioesterase (Pks13-TE) inhibitor (IC₅₀=1.30 μM). Pks13-TE inhibitor 2 shows good anti-tuberculosis activity against both agent-sensitive and drug-resistant Mtb strains (MIC=0.0039-0.0078 μg/mL). Pks13-TE inhibitor 2 can be used in studies of multidrug-resistant TB and extensively drug-resistant TB .

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Pks13-TE inhibitor 3

Cat. No.: HY-151599

CAS No.: 3031462-62-8

Target:

Bacterial

Research Areas:

Infection

Pks13-TE inhibitor 3 (compound 23) is a 13-Thioesterase (Pks13-TE) inhibitor (IC₅₀=1.55 μM). Pks13-TE inhibitor 3 shows good anti-tuberculosis activity against both agent-sensitive and drug-resistant Mtb strains (MIC=0.0625-0.25 μg/mL). Pks13-TE inhibitor 3 can be used in studies of multidrug-resistant TB and extensively drug-resistant TB .

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Pks13-TE inhibitor 4

Cat. No.: HY-155460

CAS No.: 3032947-26-2

Target:

Bacterial

Research Areas:

Infection

Pks13-TE inhibitor 4 (compound 44) is an oxadiazole series Pks13 inhibitor that effectively inhibits tuberculosis (TB) and resolves its drug resistance .

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CMX410

Cat. No.: HY-162094

CAS No.: 3027135-80-1

Target:

Acyltransferase Bacterial

Research Areas:

Infection

CMX410 is an orally active and selective Mycobacterium tuberculosis Pks13 acyltransferase domain inhibitor and anti-bacterial agent. CMX410 reacts with the catalytic serine of the Pks13-AT domain to form a stable β-lactam ring, disables the enzyme’s active site, reduces trehalose monomycolate and trehalose dimycolate levels, triggers cell lysis, and reduces intracellular bacterial burden. CMX410 can be used for the research of tuberculosis .

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Pks13-IN-3

Cat. No.: HY-181745

Target:

Bacterial

Research Areas:

Infection

Pks13-IN-3 is a furo[2,3-b]isoquinoline derivative and Pks13 inhibitor with an IC₅₀ of 1.12 μM. Pks13-IN-3 reduces inhibition of the hERG ion channel. Pks13-IN-3 can be used for the research of tuberculosis .

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Pks13-IN-1

Cat. No.: HY-170575

Target:

Bacterial

Research Areas:

Infection

Pks13-IN-1 (Compound 44) is an orally active inhibitor for Mycobacterium tuberculosis Polyketide synthase 13 (Pks13). Pks13-IN-1 inhibits M. tuberculosis strain H37Rv with a MIC of 0.07 μM. Pks13-IN-1 exhibits antibacterial efficacy in mouse model .

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(R,S,S,S)-Orlistat

Cat. No.: HY-172298

CAS No.: 104872-28-8

Synonyms: (R,S,S,S)-Tetrahydrolipstatin; (R,S,S,S)-Ro-18-0647

Target:

Fatty Acid Synthase (FASN)

Research Areas:

Infection

(R,S,S,S)-Orlistat is a stereogenic derivative of orlistat (tetrahydrolipstatin; THL) (HY-B0218). (R,S,S,S)-Orlistat inhibits three Mycobacterium tuberculosis lipid esterases, Ag85C (KI: 16.43 μM), Rv3802 (EC50: 16.2 nM), and Pks13-TE .

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