92 Results for "

Plasma stability

" in MedChemExpress (MCE) Product Catalog:
Products (92)

92 Results for "Plasma stability" in MCE Product Catalog:

5
LOC14
LOC14
0 Images
5 Cited Publications
Cat. No.: HY-100432
CAS No.: 877963-94-5
Purity:  ≥98.0%
Target:  

PDI

Research Areas:  

Neurological Disease Inflammation/Immunology

LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC50 and Kd values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding . LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells .
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4
TAK-683 acetate
TAK-683 acetate
0 Images
4 Cited Publications
Cat. No.: HY-P2161B
Target:  

Kisspeptin Receptor

Research Areas:  

Cancer

TAK-683 acetate is a potent full KISS1 receptor (KISS1R) agonist (IC50=170 pM) with improved metabolic stability. TAK-683 acetate is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC50 values of 0.96 nM and 1.6 nM for human and rat, respectively . TAK-683 acetate depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer .
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3
Zotiraciclib
Zotiraciclib
0 Images
3 Cited Publications
Cat. No.: HY-15163
CAS No.: 1204918-72-8
Synonyms: TG02; SB1317
Target:  

JAK CDK FLT3

Research Areas:  

Cancer

Zotiraciclib (TG02; SB1317) is an orally active JAK2/FLT3/CDK2 inhibitor with IC50 values of 13 nM, 73 nM and 56 nM , respectively. Zotiraciclib inhibits cancer cell proliferation, tumor growth and the activity of CYP2D6. Zotiraciclib exhibits high plasma protein binding rate, Caco-2 permeability and tissue distribution capacity, as well as metabolic stability in human and canine liver microsomes. Zotiraciclib achieves tumor growth inhibition in nude mouse models of colon cancer and lymphoma xenografts. Zotiraciclib can be used for research related to colon cancer, B-cell lymphoma, advanced leukemia, acute leukemia and multiple myeloma .
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2
TRITC-dextran, MW 4000
TRITC-dextran, MW 4000
0 Images
2 Cited Publications
Cat. No.: HY-158082
Synonyms: Tetramethyl rhodamine isothiocyanate glucan, MW 4000
Target:  

Fluorescent Dye

Research Areas:  

Others

TRITC-dextran MW 4000 (Tetramethyl rhodamine isothiocyanate glucan, MW 4000) is a fluorescent dye, with the molecular weight of 4 kD. TRITC-dextran MW 4000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 4000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 4000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .
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1
BI-4924
BI-4924
0 Images
1 Cited Publications
Cat. No.: HY-126254
CAS No.: 2244452-09-1
Purity:  99.55%
Target:  

Phosphoglycerate Dehydrogenase (PHGDH)

Research Areas:  

Cancer

BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC50 of 2200 nM at 72 h .
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Guaiol
Guaiol
0 Images
1 Cited Publications
Cat. No.: HY-N3980
CAS No.: 489-86-1
Synonyms: Champacol; Guaiac alcohol
Category:  

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