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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
Plumbagin
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "Plumbagin" in MCE Product Catalog:
8
Category:
Plumbago zeylanica Linn. Extract Anti-aging Naphthalene Quinones Quinones Plant Plumbaginaceae Extract Monophenols Phenols Disease Research Fields Cancer
Target:
Category:
Quinones Plant Plumbaginaceae Extract Plumbago zeylanica Linn. Extract Monophenols Phenols Naphthalene Quinones
Target:
Cat. No.: HY-169830
CAS No.: 3033734-59-4
Target:
Research Areas:
2-(Cyclohexylmethyl)-plumbagin is a derivative of the naphthoquinone compound Plumbagin (HY-N1497). Under nutrient-deprived conditions, 2-(Cyclohexylmethyl)-plumbagin selectively exhibits cytotoxicity against PANC-1 human pancreatic cancer cells (PC50 = 0.11 µM) and reduces the phosphorylation of Akt and mTOR in PANC-1 cells. 2-(Cyclohexylmethyl)-plumbagin also induces apoptosis (Apoptosis) in PANC-1 cells at a concentration of 1 µM. Additionally, 2-(Cyclohexylmethyl)-plumbagin reduces tumor volume and weight in a xenograft MiaPaCa-2 pancreatic cancer mouse model .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
