1 Result for "

Pratol

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Pratol" in MCE Product Catalog:

Pratol
Pratol
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Cat. No.: HY-N8719
CAS No.: 487-24-1
Synonyms: 7-Hydroxy-4'-methoxyflavone
Category:  

Flavonoids Flavones Leguminosae Extract Plants Trifolium pratense Linn.

Target:  

NF-κB PGE synthase TNF Receptor Interleukin Related p38 MAPK JNK ERK Akt PKA Microphthalmia Associated Transcription Factor (MITF) TRP Channel NO Synthase COX IKK

Pratol (7-Hydroxy-4'-methoxyflavone) is an NF-κB inhibitor. Pratol also inhibits NO, PGE2, TNF-α, IL-1β, and IL-6 production. Pratol increases the phosphorylation of p38 MAPK, JNK, and ERK, decreases AKT phosphorylation, and upregulates MITF, tyrosinase, TRP-1, and TRP-2 through a PKA-dependent signaling pathway. Pratol reduces iNOS and COX-2 protein expression, inhibits p65 phosphorylation, and protects IκBα from degradation, thereby inhibiting NF-κB nuclear translocation. Pratol can be used in research on hypopigmentary disorders, inflammatory diseases, cervical cancer, and colon cancer .
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