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40 Results for "

Pro-inflammatory effector

" in MedChemExpress (MCE) Product Catalog:

Products (40)

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Aluminum Hydroxide

8 Publications Verification

Cat. No.: HY-B1521

CAS No.: 21645-51-2

Target:

Environmental Pollutants NOD-like Receptor (NLR)

Research Areas:

Cardiovascular Disease Inflammation/Immunology

Aluminum Hydroxide is an orally active main form of aluminum used as adjuvant. Aluminum hydroxide-based adjuvant researches include the repository effect, pro-phagocytic effect, and activation of the pro-inflammatory NLRP3 pathway. Aluminum Hydroxide also acts as adjuvant to compensate low inherent immunogenicity of subunit vaccines .

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7-Ketocholesterol

7 Cited Publications

Cat. No.: HY-113342

CAS No.: 566-28-9

Purity: 99.87%

Category:

Triterpenes Terpenoids Endogenous metabolite

Target:

Endogenous Metabolite p38 MAPK

7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bile acid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis (apoptosis) .

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Gabexate mesylate

4 Cited Publications

Cat. No.: HY-B0385

CAS No.: 56974-61-9

Synonyms: FOY

Target:

Proteasome Factor Xa

Research Areas:

Inflammation/Immunology

Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with K_is of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with K_is of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation .

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STAT1/3-IN-1

3 Cited Publications

Cat. No.: HY-170621

CAS No.: 2958649-56-2

Target:

STAT NO Synthase COX Interleukin Related TNF Receptor

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

STAT1/3-IN-1 is a potent STAT1/3 inhibitor with potent anti-inflammatory effect. STAT1/3-IN-1 inhibits phosphorylation and nuclear translocation of STAT1/3 to modulate microglial inflammation, reduces LPS (HY-D1056)-induced pro-inflammatory cytokines (NO, IL-1β, IL-6, and TNF-α) and inflammatory mediators (iNOS, COX-2). STAT1/3-IN-1 exhibits low toxicity in mice. STAT1/3-IN-1 can be used for the research of neuroinflammation .

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