10084 Results for "

Protection against convulsion

" in MedChemExpress (MCE) Product Catalog:

Products (10084)

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2156

Protease Inhibitor Cocktail (EDTA-Free, 100× in DMSO)

2156 Publications Verification

Cat. No.: HY-K0010

MCE Protease Inhibitor Cocktail (EDTA-Free, 100× in DMSO) is a blend of 6 pan-protease inhibitors for protection of protein integrity.The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

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271

Protease Inhibitor Cocktail, mini-Tablet (EDTA-Free)

271 Cited Publications

Cat. No.: HY-K0011

MCE Protease Inhibitor Cocktail, mini-Tablet (EDTA-Free) is a blend of 5 pan-protease inhibitors for protection of protein integrity. The 25 pcs is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

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214

Osimertinib

214 Cited Publications

Cat. No.: HY-15772

CAS No.: 1421373-65-0

Purity: 99.92%

Synonyms: AZD-9291; Mereletinib

Target:

EGFR

Research Areas:

Cancer

Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC₅₀ of 12 nM against L858R and 1 nM against L858R/T790M, respectively. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer .

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214

Osimertinib mesylate

214 Cited Publications

Cat. No.: HY-15772A

CAS No.: 1421373-66-1

Purity: 99.97%

Synonyms: AZD-9291 mesylate; Mereletinib mesylate

Target:

EGFR

Research Areas:

Cancer

Osimertinib mesylate (AZD9291 mesylate) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC₅₀ of 12 nM against L858R and 1 nM against L858R/T790M. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer .

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214

Osimertinib dimesylate

214 Cited Publications

Cat. No.: HY-79077

CAS No.: 2070014-82-1

Synonyms: AZD-9291 dimesylate; Mereletinib dimesylate

Target:

EGFR

Research Areas:

Cancer

Osimertinib dimesylate (AZD-9291 dimesylate) is an irreversible and mutant selective EGFR inhibitor with IC₅₀s of 12 and 1 nM against EGFR ^L858R and EGFR ^L858R/T790M, respectively.

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213

Temozolomide

213 Cited Publications

Cat. No.: HY-17364

CAS No.: 85622-93-1

Synonyms: NSC 362856; CCRG 81045; TMZ

Target:

DNA Alkylator/Crosslinker Autophagy Apoptosis

Research Areas:

Cancer

Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .

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182

ATP

182 Cited Publications

Cat. No.: HY-B2176

CAS No.: 56-65-5

Synonyms: Adenosine 5'-triphosphate

Category:

Plants Other Families Extract Endogenous metabolite Alkaloids Human Gut Microbiota Metabolites Microorganisms Animals Other Alkaloids Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial

ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice .

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168

Mitoquinone mesylate

168 Cited Publications

Cat. No.: HY-100116A

CAS No.: 845959-50-4

Purity: 99.09%

Synonyms: MitoQ mesylate; MitoQ10 mesylate

Target:

Reactive Oxygen Species (ROS)

Research Areas:

Metabolic Disease Cancer

Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant in order to protect against oxidative damage .

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163

Mirdametinib

163 Cited Publications

Cat. No.: HY-10254

CAS No.: 391210-10-9

Purity: 99.95%

Synonyms: PD0325901; PD325901

Target:

MEK Autophagy Apoptosis

Research Areas:

Cancer

Mirdametinib (PD0325901) is an orally active, selective and non-ATP-competitive MEK inhibitor with an IC₅₀ of 0.33 nM. Mirdametinib exhibits a K_i ^app of 1 nM against activated MEK1 and MEK2. Mirdametinib suppresses the expression of p-ERK1/2 and induces apoptosis. Mirdametinib has anti-cancer activity for a broad spectrum of human tumor xenografts .

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148

A 83-01 sodium

148 Cited Publications

Cat. No.: HY-10432A

CAS No.: 2828431-89-4

Purity: 98.43%

Target:

Organoid TGF-β Receptor

Research Areas:

Cancer

A 83-01 sodium is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC₅₀s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively .

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148

A 83-01

148 Cited Publications

Cat. No.: HY-10432

CAS No.: 909910-43-6

Purity: 99.33%

Target:

Organoid TGF-β Receptor

Research Areas:

Cancer

A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC₅₀s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively .

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