326 Results for "

Psoriasis

" in MedChemExpress (MCE) Product Catalog:
Products (326)

326 Results for "Psoriasis" in MCE Product Catalog:

94
Methotrexate
Methotrexate
0 Images
94 Publications Verification
Cat. No.: HY-14519
CAS No.: 59-05-2
Purity:  99.87%
Synonyms: Amethopterin; CL14377; WR19039
Target:  

Antifolate Dihydrofolate reductase (DHFR) NO Synthase COX Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Methotrexate (Amethopterin; CL14377; WR19039) is an orally active antifolate (Antifolate). Methotrexate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .
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94
Methotrexate hydrate
Methotrexate hydrate
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94 Publications Verification
Cat. No.: HY-14519B
CAS No.: 133073-73-1
Purity:  98.41%
Synonyms: Amethopterin hydrate; CL14377 hydrate; WR19039 hydrate
Target:  

Antifolate Dihydrofolate reductase (DHFR) NO Synthase COX Interleukin Related

Methotrexate hydrate (Amethopterin hydrate; CL14377 hydrate; WR19039 hydrate) is an orally active antifolate (Antifolate). Methotrexate hydrate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate hydrate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate hydrate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate hydrate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .
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94
Methotrexate disodium
Methotrexate disodium
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94 Publications Verification
Cat. No.: HY-14519A
CAS No.: 7413-34-5
Purity:  99.71%
Synonyms: Amethopterin disodium; CL14377 disodium; WR19039 disodium
Target:  

Antifolate Dihydrofolate reductase (DHFR) NO Synthase COX Interleukin Related

Methotrexate disodium (Amethopterin disodium; CL14377 disodium; WR19039 disodium) is an orally active antifolate (Antifolate). Methotrexate disodium inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate disodium promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate disodium induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate disodium is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .
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72
IWR-1
IWR-1
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72 Cited Publications
Cat. No.: HY-12238
CAS No.: 1127442-82-3
Purity:  99.60%
Synonyms: endo-IWR 1; IWR-1-endo
Target:  

Organoid Wnt

Research Areas:  

Inflammation/Immunology Cancer

IWR-1 (IWR-1-endo) is a tankyrase inhibitor targeting Wnt/β-catenin (IC50 = 180 nM). IWR-1 compromises critical steps of the canonical Wnt signaling, namely translocation of β-catenin to the nucleus and subsequent TCF/LEF activation and expression of Wnt/β-catenin downstream targets. IWR-1 promotes β-catenin phosphorylation by promoting stability of Axin-scaffolded destruction complexes. IWR-1 can be studied in research for anti-tumor purposes, and diseases such as osteosarcoma, colorectal cancer and psoriasis .
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38
Deucravacitinib
Deucravacitinib
0 Images
38 Cited Publications
Cat. No.: HY-117287
CAS No.: 1609392-27-9
Purity:  99.87%
Synonyms: BMS-986165
Deucravacitinib (BMS-986165) is an orally active allosteric inhibitor of tyrosine kinase 2 (TYK2), with an IC50 of 0.2 nM and a Ki of 0.02 nM against the JH2 domain of TYK2, and it exhibits selectivity over other JAK subtypes and most of the kinome. Deucravacitinib blocks IL-23, IL-12, p-STAT1/3 and Type I IFN signaling, and inhibits Th17/Th1-mediated psoriasis inflammation . Deucravacitinib can be used in research related to moderate-to-severe plaque psoriasis, inflammatory bowel disease and systemic lupus erythematosus .
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19
Enpatoran
Enpatoran
0 Images
19 Cited Publications
Cat. No.: HY-134581
CAS No.: 2101938-42-3
Purity:  99.80%
Synonyms: M5049
Target:  

Toll-like Receptor (TLR) IFNAR

Research Areas:  

Inflammation/Immunology

Enpatoran (M5049) is an orally active and selective TLR7/8 antagonist. Enpatoran inhibits the activation of the downstream type I interferon pathway. Enpatoran is used in studies of cutaneous lupus erythematosus, systemic lupus erythematosus with cutaneous manifestations, and psoriasis .
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19
Enpatoran hydrochloride
Enpatoran hydrochloride
0 Images
19 Cited Publications
Cat. No.: HY-134581A
CAS No.: 2101945-93-9
Purity:  99.42%
Synonyms: M5049 hydrochloride
Target:  

Toll-like Receptor (TLR) IFNAR

Research Areas:  

Inflammation/Immunology

Enpatoran hydrochloride (M5049 hydrochloride) is an orally active and selective TLR7/8 antagonist. Enpatoran hydrochloride inhibits the activation of the downstream type I interferon pathway. Enpatoran hydrochloride is used in studies of cutaneous lupus erythematosus, systemic lupus erythematosus with cutaneous manifestations, and psoriasis .
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17
Methoxsalen
Methoxsalen
0 Images
17 Cited Publications
Cat. No.: HY-30151
CAS No.: 298-81-7
Synonyms: 8-Methoxypsoralen; Xanthotoxin; 8-MOP
Category:  

Coumarins Phenylpropanoids Plants Other Families Extract Disease Research Fields Cancer

Target:  

Cytochrome P450

Methoxsalen (8-Methoxypsoralen) is a furanocoumarin compound used in psoralen, used in studies of psoriasis, eczema, vitiligo and some sun-exposed cutaneous lymphomas, and is a P450 inhibitor.
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16
Etanercept
Etanercept
0 Images
16 Cited Publications
Cat. No.: HY-108847
CAS No.: 185243-69-0
Purity:  99.20%

Target:  

TNF Receptor Bacterial

Research Areas:  

Inflammation/Immunology Cancer

Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis .
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13
Secukinumab (Anti-Human IL-17A)
Secukinumab (Anti-Human IL-17A)
0 Images
13 Cited Publications
Cat. No.: HY-P9927A
CAS No.: 1229022-83-6

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Secukinumab (Anti-Human IL-17A) is a fully human anti-interleukin-17A monoclonal antibody. Anti-Human IL-17A can be used for research in psoriasis pathogenesis .
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13
Secukinumab
Secukinumab
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13 Cited Publications
Cat. No.: HY-P9927
CAS No.: 1229022-83-6
Synonyms: AIN457

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Secukinumab (AIN457) is a high affinity, human monoclonal antibody targeted against interleukin (IL)-17A. Secukinumab is the first-in-class anti-IL-17 agent used for the research of plaque psoriasis, ankylosing spondylitis and psoriatic arthritis .
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7
PD 151746
PD 151746
0 Images
7 Cited Publications
Cat. No.: HY-19749
CAS No.: 181765-30-0
Target:  

Proteasome Interleukin Related

Research Areas:  

Cardiovascular Disease Inflammation/Immunology Cancer

PD 151746 is a selective calpain-1 inhibitor with an IC50 of 260 nM. PD 151746 binds μ-calpain Ca 2+-binding sites, and shows selectivity over cathepsin B, papain, trypsin, thermolysin, and basal calcineurin. PD 151746 reduces Oxidized low-density lipoprotein (oxLDL)-induced cytotoxicity, apoptotic DNA fragmentation, and blocks IL-1α maturation. PD 151746 can be used for the research of atherosclerosis and psoriasis .
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5
Brodalumab
Brodalumab
0 Images
5 Cited Publications
Cat. No.: HY-P9925
CAS No.: 1174395-19-7
Synonyms: AMG 827; KHK4827

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Brodalumab (AMG 827) is a human anti-interleukin-17-receptor IgG2 monoclonal antibody that can be used for the research of moderate-to-severe plaque psoriasis and rheumatoid arthritis .
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4
Acitretin
Acitretin
0 Images
4 Cited Publications
Cat. No.: HY-B0107
CAS No.: 55079-83-9
Synonyms: Ro 10-1670
Target:  

RAR/RXR Autophagy Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Acitretin (Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis. Acitretin also can be used for the research of Alzheimer’s disease .
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4
Maxacalcitol
Maxacalcitol
0 Images
4 Cited Publications
Cat. No.: HY-32339
CAS No.: 103909-75-7
Synonyms: 22-Oxacalcitriol
Target:  

VD/VDR

Research Areas:  

Metabolic Disease Inflammation/Immunology Endocrinology

Maxacalcitol (22-Oxacalcitriol), a vitamin D3 (HY-15398) analog, is an orally active VDR agonist. Maxacalcitol has a limited calcemic effect. Maxacalcitol has the potential for psoriasis and hyperparathyroidism research .
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4
Fenoldopam mesylate
Fenoldopam mesylate
0 Images
4 Cited Publications
Cat. No.: HY-B0735A
CAS No.: 67227-57-0
Synonyms: Fenoldopam methanesulfonate; SKF-82526 mesylate
Target:  

Dopamine Receptor

Research Areas:  

Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer

Fenoldopam (SKF-82526) mesylate is a selective dopamine D1 receptor agonist. Fenoldopam mesylate binds to rat D1B dopamine receptors (Kd = 11 nM) and human D1A receptors (Kd = 17 nM) in COS-7 cell membranes expressing the cloned receptors. Fenoldopam mesylate modulates dopamine receptor expression, induces vasorelaxation in vascular tissues, reverses glomerular hyperfiltration in rat models, increases intracellular cAMP levels, promotes DARPP-32 phosphorylation in small cell lung cancer (SCLC) cells, inhibits cytokine secretion, and downregulates T cell activation markers in activated human T cells. Fenoldopam mesylate can be used for research on hypertension, acute kidney injury, psoriasis, and small cell lung cancer .
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3
AZD-0284
AZD-0284
0 Images
3 Cited Publications
Cat. No.: HY-120384
CAS No.: 2101291-07-8
Purity:  99.90%
Target:  

ROR

Research Areas:  

Inflammation/Immunology

AZD-0284 is a selective inverse agonist of the nuclear receptor RORγ. AZD-0284 has the potential for plaque psoriasis vulgaris and respiratory tract disorders treatment .
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3
Khasianine
Khasianine
0 Images
3 Cited Publications
Cat. No.: HY-N2322
CAS No.: 32449-98-2
Category:  

Alkaloids Piperidine Alkaloids 500 - Internal Server Error | MedChemExpress

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