6717 Results for "

Purge factor

" in MedChemExpress (MCE) Product Catalog:
Products (6717)

6717 Results for "Purge factor" in MCE Product Catalog:

415
Dexamethasone
Dexamethasone
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415 Publications Verification
Cat. No.: HY-14648
CAS No.: 50-02-2
Purity:  99.86%
Synonyms: Hexadecadrol; Prednisolone F
Target:  

Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic ADC Payloads

Research Areas:  

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist, apoptosis inducer, and common disease inducer in experimental animals, constructing models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has potential for use in COVID-19 research .
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415
Dexamethasone (Water Soluble)
Dexamethasone (Water Soluble)
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415 Publications Verification
Cat. No.: HY-14648C
CAS No.: 50-02-2
Purity:  ≥98.0%
Synonyms: Dexamethasone cyclodextrin complex
Target:  

Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic

Research Areas:  

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Dexamethasone (Hexadecadrol) Water Soluble is a water-soluble form of Dexamethasone (HY-14648). Dexamethasone is a glucocorticoid receptor agonist, apoptosis inducer, and a common disease inducer in experimental animals. It can be used to construct models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has the potential to be used in COVID-19 research .(Sale size is the weight of dexamethasone)
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223
Cyclosporin A
Cyclosporin A
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223 Cited Publications
Cat. No.: HY-B0579
CAS No.: 59865-13-3
Synonyms: Cyclosporine A; Ciclosporin A; CsA
Category:  

Natural Products Microorganisms Anti-aging Disease Research Fields Inflammation/Immunology Cancer

Target:  

Molecular Glues Complement System Antibiotic Cyclophilin

Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM . Cyclosporin A is a molecular glue, binds to cyclophilin and calcineurin, leading to inactivation of nuclear Factor of activated T Cells (NFAT) and a subsequent decrease in the immune response. Cyclosporin A also inhibits CD11a/CD18 adhesion .
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182
TGF beta 1/TGFB1 Protein, Human (CHO)
TGF beta 1/TGFB1 Protein, Human (CHO)
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182 Cited Publications
Cat. No.: HY-P7118
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFB1; Transforming Growth factor Beta1; Prev. TGFB; Camurati-Engelmann Disease; Prev. DPD1; Latency-Associated Peptide; TGFbeta; TGF-Beta-1; CED; TGF-Beta1; Transforming Growth factor Beta-1 Proprotein; IBDIMDE; Prepro-Transforming Growth factor Beta-1;
Species:  
Human
Source:  
CHO
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181
Pexidartinib hydrochloride
Pexidartinib hydrochloride
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181 Cited Publications
Cat. No.: HY-16749A
CAS No.: 2040295-03-0
Synonyms: PLX-3397 hydrochloride
Target:  

c-Fms c-Kit Apoptosis

Research Areas:  

Cancer

Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity .
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181
Pexidartinib
Pexidartinib
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181 Cited Publications
Cat. No.: HY-16749
CAS No.: 1029044-16-3
Synonyms: PLX-3397
Target:  

c-Fms c-Kit Apoptosis

Research Areas:  

Cancer

Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity. Pexidartinib has limited permeability to the blood-brain barrier, primarily through ABCB1 .
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156
Retinoic acid
Retinoic acid
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156 Cited Publications
Cat. No.: HY-14649
CAS No.: 302-79-4
Purity:  99.81%
Synonyms: Vitamin A acid; all-trans-Retinoic acid; ATRA
Category:  

Ketones, Aldehydes, Acids Whitening Agent Cosmetic Research Endogenous metabolite Disease Research Fields Cancer

Target:  

Organoid RAR/RXR PPAR Endogenous Metabolite Autophagy

Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.
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155
M-CSF Protein, Mouse
M-CSF Protein, Mouse
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155 Cited Publications
Cat. No.: HY-P7085
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CSF1; Macrophage Colony Stimulating factor 1; Colony Stimulating factor 1; Lanimostim; MCSF; MGC31930; Proteoglycan Macrophage Colony-Stimulating factor; PG-M-CSF; Macrophage Colony-Stimulating factor 1; CSF-1; M-CSF; CSF1-HERV-LTR71B Fusion Protein; Colo
Species:  
Mouse
Source:  
E. coli
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154
Necrosulfonamide
Necrosulfonamide
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154 Cited Publications
Cat. No.: HY-100573
CAS No.: 1360614-48-7
Purity:  99.47%
Target:  

Mixed Lineage Kinase Necroptosis Pyroptosis Caspase NOD-like Receptor (NLR) Keap1-Nrf2 TNF Receptor Interleukin Related NO Synthase Heme Oxygenase (HO)

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology

Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinson’s disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways .
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122
Yoda 1
Yoda 1
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122 Cited Publications
Cat. No.: HY-18723
CAS No.: 448947-81-7
Target:  

Piezo Channel Akt ERK Potassium Channel

Research Areas:  

Cardiovascular Disease

Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca 2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation .
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113
T-5224
T-5224
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113 Cited Publications
Cat. No.: HY-12270
CAS No.: 530141-72-1
Purity:  99.03%
Target:  

AP-1 MMP

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .
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109
EGF Protein, Human
EGF Protein, Human
0 Images
109 Cited Publications
Cat. No.: HY-P7109
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: EGF; Alternative Protein EGF; Epidermal Growth factor; Beta-Urogastrone; Pro-Epidermal Growth factor; HOMG4; Epidermal Growth factor (Beta-Urogastrone); URG
Species:  
Human
Source:  
E. coli
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78
TNF-alpha/TNFSF2 Protein, Human
TNF-alpha/TNFSF2 Protein, Human
0 Images
78 Cited Publications
Cat. No.: HY-P7058
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNF; Tumor Necrosis factor (TNF Superfamily, Member 2); Prev. TNFA; Tumor Necrosis factor-Alpha; TNF-Alpha; Tumor Necrotic factor Alpha; TNFSF2; TNF Superfamily, Member 2; Tumor Necrosis factor Ligand Superfamily Member 2; TNF, Macrophage-Derived; TNF-A; TNF, Monocyte-Derived; DIF; APC1 Protein; Cachectin; IMD127; TNLG1F; Tumor Necrosis factor; Tumor Necrosis factor Ligand 1F
Species:  
Human
Source:  
E. coli
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76
TGF beta 1/TGFB1 Protein, Mouse/Rat (HEK293, Tag Free)
TGF beta 1/TGFB1 Protein, Mouse/Rat (HEK293, Tag Free)
0 Images
76 Cited Publications
Cat. No.: HY-P7117
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFB1; Transforming Growth factor Beta1; Prev. TGFB; Camurati-Engelmann Disease; Prev. DPD1; Latency-Associated Peptide; TGFbeta; TGF-Beta-1; CED; TGF-Beta1; Transforming Growth factor Beta-1 Proprotein; IBDIMDE; Prepro-Transforming Growth factor Beta-1;
Species:  
Rat Mouse
Source:  
HEK293
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76
Minocycline hydrochloride
Minocycline hydrochloride
0 Images
76 Cited Publications
Cat. No.: HY-17412
CAS No.: 13614-98-7
Target:  

Bacterial Antibiotic HIF/HIF Prolyl-Hydroxylase Apoptosis MDM-2/p53 Potassium Channel Calcium Channel

Research Areas:  

Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline hydrochloride shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .
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76
Minocycline
Minocycline
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76 Cited Publications
Cat. No.: HY-17412A
CAS No.: 10118-90-8
Target:  

Antibiotic Bacterial HIF/HIF Prolyl-Hydroxylase Apoptosis MDM-2/p53 Potassium Channel Calcium Channel

Research Areas:  

Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .
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75
Camptothecin
Camptothecin
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75 Cited Publications
Cat. No.: HY-16560
CAS No.: 7689-03-4
Synonyms: Campathecin; (S)-(+)-Camptothecin; CPT
Category:  

Infection Nyssaceae Extract Alkaloids Quinoline Alkaloids 500 - Internal Server Error | MedChemExpress

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