8

Trovafloxacin mesylate

8 Publications Verification

Cat. No.: HY-103399

CAS No.: 147059-75-4

Purity: 99.76%

Target:

Bacterial Topoisomerase Antibiotic

Research Areas:

Infection

Trovafloxacin mesylate is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin mesylate blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin mesylate is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC₅₀ of 4 μM for PANX1 inward current. Trovafloxacin mesylate does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin mesylate leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1 .

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8

Trovafloxacin

8 Publications Verification

Cat. No.: HY-A0170

CAS No.: 147059-72-1

Target:

Bacterial Topoisomerase Antibiotic

Research Areas:

Infection

Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC₅₀ of 4 μM for PANX1 inward current. Trovafloxacin does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1 .

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3

Nalidixic acid

3 Cited Publications

Cat. No.: HY-B0398

CAS No.: 389-08-2

Category:

Infection Microorganisms Antibiotics Resistance Selection Disease Research Antibacterial Disease Research Fields Other Antibiotics

Target:

Bacterial Antibiotic Topoisomerase

Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .

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3

Flumequine

3 Cited Publications

Cat. No.: HY-B0526

CAS No.: 42835-25-6

Synonyms: R-802

Target:

Bacterial Topoisomerase Antibiotic

Research Areas:

Infection Cancer

Flumequine (R-802) is a quinolone antibiotic, and acts as a topoisomerase II inhibitor, with an IC₅₀ of 15 μM (3.92 μg/mL).

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3

Nalidixic acid sodium salt

3 Cited Publications

Cat. No.: HY-B0398A

CAS No.: 3374-05-8

Target:

Bacterial Antibiotic Topoisomerase

Research Areas:

Infection

Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .

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2

Pseudomonas quinolone signal

2 Cited Publications

Cat. No.: HY-128200

CAS No.: 108985-27-9

Purity: 99.84%

Synonyms: PQS

Target:

Bacterial

Research Areas:

Infection Inflammation/Immunology

Pseudomonas quinolone signal (PQS) is a quorum-sensing signaling molecule produced by Pseudomonas aeruginosa. The synthesis of Pseudomonas quinolone signal relies on the las quorum-sensing system, and its biological activity is associated with the rhl system. Pseudomonas quinolone signal regulates the expression of the virulence gene lasB. Additionally, Pseudomonas quinolone signal plays roles in iron acquisition, cytotoxicity, outer-membrane vesicle biogenesis, and host immune modulation .

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2

CMS-121

2 Cited Publications

Cat. No.: HY-135981

CAS No.: 1353224-53-9

Purity: 98.30%

Target:

Acetyl-CoA Carboxylase

Research Areas:

Neurological Disease Inflammation/Immunology

CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC₅₀ values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities .

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1

Cinoxacin

1 Cited Publications

Cat. No.: HY-B1085

CAS No.: 28657-80-9

Synonyms: Compound 64716

Target:

Bacterial Antibiotic DNA/RNA Synthesis

Research Areas:

Infection

Cinoxacin (Compound 64716), a synthetic antimicrobial related to the quinolone class of orally active antibacterial agent. Cinoxacin has antibacterial activity against many gram-negative aerobic bacteria and inhibits bacterial DNA synthesis. Cinoxacin can be used for the research of urinary tract infections and bacterial prostatitis .

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1

Rosoxacin

1 Cited Publications

Cat. No.: HY-A0208

CAS No.: 40034-42-2

Synonyms: Acrosoxacin

Target:

Bacterial Antibiotic

Research Areas:

Infection

Rosoxacin (Acrosoxacin) is an orally active and broad-spectrum antibacterial quinolone antibiotic. Rosoxacin inhibits Gram-negative bacteria, including N. gonorrhoeae (MIC range=0.03-0.125 µg/mL).Rosoxacin can be used in studies of urinary tract infections and certain sexually transmitted diseases .

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1

8-Hydroxycoumarin

1 Cited Publications

Cat. No.: HY-21509

CAS No.: 2442-31-1

Target:

NADPH Oxidase

Research Areas:

Others

8-Hydroxycoumarin is an intermediate in the microbial transformation of quinolone .

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1

Nemonoxacin malate

1 Cited Publications

Cat. No.: HY-111023

CAS No.: 951163-60-3

Purity: 99.43%

Synonyms: TG-873870 malate

Target:

Antibiotic Bacterial

Research Areas:

Infection

Nemonoxacin (TG-873870) malate is a nonfluorinated quinolone antibiotic. Nemonoxacin malate has broad-spectrum activity against Gram-positive, Gram-negative and atypical pathogens. Nemonoxacin malate can inhibit drug-resistant Streptococcus pneumoniae and Methicillin-resistant Staphylococcus aureus. Nemonoxacin malate can be used for the research of community-acquired pneumonia .

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1

Nadifloxacin

1 Cited Publications

Cat. No.: HY-B0506

CAS No.: 124858-35-1

Synonyms: OPC7251

Target:

Bacterial Antibiotic DNA/RNA Synthesis Interleukin Related

Research Areas:

Infection Inflammation/Immunology

Nadifloxacin (OPC7251) is a broad-spectrum quinolone antibiotic. Nadifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, interfering with DNA replication. It also suppresses the production of proinflammatory cytokines (such as IL-1α, IL-6, and IL-8). Nadifloxacin exhibits antibacterial activity against various pathogens, including Propionibacterium acnes and Staphylococcus aureus. Nadifloxacin also exhibits anti-inflammatory activity. Nadifloxacin can be used in the research of skin infections such as acne vulgaris, folliculitis, and impetigo .

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Emvistegrast

Cat. No.: HY-177080

CAS No.: 2417352-91-9

Synonyms: GS-1427

Target:

Integrin

Research Areas:

Inflammation/Immunology

Emvistegrast (GS-1427) is a quinolone derivative. Emvistegrast is also an inhibitor of α4β7 integrin. Emvistegrast can be used to investigate diseases mediated by α4β7 integrin, such as inflammatory bowel disease .

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Thermopsine

Cat. No.: HY-N5009

CAS No.: 486-90-8

Category:

Infection Alkaloids Pyridine Alkaloids 500 - Internal Server Error | MedChemExpress

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Quinolones

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