601

RSL3

601 Publications Verification

Cat. No.: HY-100218A

CAS No.: 1219810-16-8

Purity: 99.90%

Synonyms: (1S,3R)-RSL3

Target:

p62 Glutathione Peroxidase Ferroptosis Reactive Oxygen Species (ROS)

Research Areas:

Cancer

RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .

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37

iFSP1

37 Cited Publications

Cat. No.: HY-136057

CAS No.: 150651-39-1

Purity: 99.96%

Target:

Ferroptosis Ligands for Target Protein for PROTAC

Research Areas:

Cancer

iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC₅₀ of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A) .

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6

ASP3026

6 Cited Publications

Cat. No.: HY-13326

CAS No.: 1097917-15-1

Purity: 99.88%

Target:

Anaplastic lymphoma kinase (ALK) Apoptosis ROS Kinase Caspase PARP IGF-1R STAT Akt JNK

Research Areas:

Cancer

ASP3026 is a selective and orally active inhibitor of anaplastic lymphoma kinase (ALK). ASP3026 is a selective and oral active anaplastic lymphoma kinase (ALK) inhibitor with a IC₅₀ value of 3.5 nM. ASP3026 can inhibit the phosphorylation of IGF-1R, STAT3, AKT and JNK proteins, and induce the cleavage of caspase 3 and PARP. It also inhibited ROS and ACK. ASP3026 can be used in anti-tumor research ^[3] .

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5

Tropisetron

5 Cited Publications

Cat. No.: HY-B0072

CAS No.: 89565-68-4

Synonyms: SDZ-ICS-930 free base

Target:

5-HT Receptor nAChR p38 MAPK NF-κB AP-1 Nuclear Factor of activated T Cells (NFAT) JAK

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

Tropisetron is an orally active 5-HT3R antagonist (K_i = 5.3 nM) as well as being a potent and selective α7 nicotinic partial agonist (EC₅₀ = 1.3 μM). Tropisetron prevents phosphorylation and activation of the p38 MAPK. Tropisetron inhibits both IL-2 gene transcription and IL-2 synthesis in stimulated T cells. Tropisetron inhibits the binding to DNA and the transcriptional activity of NFAT and AP-1. Tropisetron is anti-inflammatory and antiemetic. Tropisetron has antitumor and neuroprotective effects. Tropisetron can be studied in research for diseases including hemorrhagic cystitis, chronic joint inflammation, lung cancer and chronic cerebral hypoperfusion ^[3] .

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4

Asenapine hydrochloride

4 Cited Publications

Cat. No.: HY-16567

CAS No.: 1412458-61-7

Synonyms: Org 5222 hydrochloride

Target:

5-HT Receptor Dopamine Receptor Adrenergic Receptor Histamine Receptor

Research Areas:

Neurological Disease

Asenapine (Org 5222) hydrochloride, an atypical antipsychotic, is an antagonist of serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i: 8.9-9.5), dopamine receptors (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0). Asenapine hydrochloride can be used in the research of schizophrenia and bipolar disorder ^[2]r .

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3

(1R,3R)-RSL3

3 Cited Publications

Cat. No.: HY-100218C

CAS No.: 1219810-15-7

Purity: 99.52%

Target:

Drug Isomer Ferroptosis

Research Areas:

Cancer

(1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .

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2

(R)-CE3F4

2 Cited Publications

Cat. No.: HY-108539A

CAS No.: 1593478-56-8

Purity: ≥99.0%

Target:

Ras

Research Areas:

Metabolic Disease

(R)-CE3F4 is a potent and selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1), with an IC₅₀ of 4.2 μM, with 10-fold selectivity for Epac1 over Epac2 (IC₅₀, 44 μM). (R)-CE3F4 is more potent than racemic CE3F4 and (S)-CE3F4 .

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