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39 Results for "

RA-2

" in MedChemExpress (MCE) Product Catalog:

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RA-2

Cat. No.: HY-118689

CAS No.: 1867107-62-7

Target:

Potassium Channel

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

RA-2 is a negative-gating modulator of KCa2/3 channels with an IC₅₀ of 17 nM. RA-2 inhibits bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in U46619-precontracted rings. RA-2 can help to define the physiologic and pathomechanistic roles of KCa2/3 in the vasculature, central nervous system, and during inflammation .

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Pep-1 (uncapped)

2 Cited Publications

Cat. No.: HY-P1848

CAS No.: 395069-86-0

Target:

Interleukin Related

Research Areas:

Cancer

Pep-1 (uncapped) is a specific ligand of IL-13Ra2. Pep-1 (uncapped) exerts cell penetrating activity through receptor-mediated endocytosis, can cross the blood-tumor barrier (BTB) and target glioma cells. Pep-1 (uncapped) can enhance the uptake of nanoparticles by tumor cells and enhance the cell penetration ability of nanoparticles, and can be used to develop targeted drug delivery systems for glioma .

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DOTA-Pep-1L TFA

Cat. No.: HY-P11287A

Target:

Research Areas:

Cancer

DOTA-Pep-1L TFA is a polypeptide formed by the conjugation of DOTA and Pep-1L. DOTA-Pep-1L TFA specifically binds to IL13RA2 and can be used for the synthesis of targeted polypeptides. DOTA-Pep-1L TFA yields the isotopically labeled product [ ²²⁵Ac]DOTA-Pep-1L, which exerts α-radiation killing effects on orthotopic glioma cells and extends the median survival time of mice bearing orthotopic glioma models after stereotactic injection. DOTA-Pep-1L TFA can be used for PET imaging, tumor targeting and glioma research ^[2].

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A2B receptor antagonist 2

Cat. No.: HY-139314

CAS No.: 784-90-7

Purity: 99.39%

Target:

Adenosine Receptor

Research Areas:

Metabolic Disease

A2B receptor antagonist 2 (compound 18) is an adenosine receptor A_2B antagonist, with K_i values of 2.30 μM, 6.8 μM and 3.44 μM for rA₁, rA_2A and hA_2B, respectively .

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NOTA-Pep-1L

Cat. No.: HY-P10292

Target:

Radionuclide-Drug Conjugates (RDCs) Interleukin Related

Research Areas:

Cancer

NOTA-Pep-1L specifically targets the IL13RA2 receptor for tumor imaging . NOTA-Pep-1L can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

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MRS1334

Cat. No.: HY-103174

CAS No.: 192053-05-7

Purity: ≥99.0%

Target:

Adenosine Receptor

Research Areas:

Cardiovascular Disease

MRS1334 is a potent and selective human adenosine A₃ receptor antagonist with K_is of 2.69 nM, >100 nM, >100 nM for hA₃, rA₁, rA_2A, respectively. MRS1334 blocks the protective effect of Cl-IB-MECA leading to significant bradycardia and elevated ST segment ^[2]. MRS1334 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Vopikitug

Cat. No.: HY-P990086

CAS No.: 2733581-99-0

Synonyms: RG-6292; RO-7296682

Vopikitug is an IgG1-kappa, anti-IL2RA (interleukin 2 receptor alpha subunit, IL-2RA, TAC, p55, CD25) homo sapiens monoclonal antibody. Vopikitug shows antineoplastic activity .

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