595

Necrostatin-1

595 Publications Verification

Cat. No.: HY-15760

CAS No.: 4311-88-0

Purity: 99.89%

Synonyms: Nec-1

Target:

RIP kinase Autophagy Indoleamine 2,3-Dioxygenase (IDO) Ferroptosis Necroptosis

Research Areas:

Cancer

Necrostatin-1 (Nec-1) is a potent and cross the blood-brain barrier necroptosis inhibitor with an EC₅₀ of 490 nM in Jurkat cells. Necrostatin-1 inhibits RIP1 kinase (EC₅₀=182 nM). Necrostatin-1 is also an IDO inhibitor .

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119

GSK-872

119 Cited Publications

Cat. No.: HY-101872

CAS No.: 1346546-69-7

Purity: 99.80%

Target:

RIP kinase

Research Areas:

Inflammation/Immunology

GSK-872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC₅₀ of 1.8 nM, and inhibits kinase activity with an IC₅₀ of 1.3 nM. GSK-872 decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury .

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119

GSK-872 hydrochloride

119 Cited Publications

Cat. No.: HY-101872A

CAS No.: 2703752-81-0

Purity: 99.21%

Target:

RIP kinase

Research Areas:

Inflammation/Immunology

GSK-872 hydrochloride is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC₅₀ of 1.8 nM, and inhibits kinase activity with an IC₅₀ of 1.3 nM. GSK-872 hydrochloride decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury .

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9

GSK2982772

9 Cited Publications

Cat. No.: HY-101760

CAS No.: 1622848-92-3

Purity: 99.79%

Target:

RIP kinase

Research Areas:

Infection Neurological Disease Inflammation/Immunology

GSK2982772 is a potent, orally active and ATP competitive RIP1 kinase inhibitor with IC₅₀ values of 16 nM and 20 nM for human and monkey RIP1, respectively .

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9

GSK583

9 Cited Publications

Cat. No.: HY-100339

CAS No.: 1346547-00-9

Purity: 99.93%

Target:

RIP kinase

Research Areas:

Endocrinology

GSK583 is a highly potent, orally active and selective inhibitor of RIP2 Kinase, with IC₅₀ of 5 nM. GSK583 inhibits both TNF-α and IL-6 production with an IC₅₀ value of 200 nM.

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8

GSK-843

8 Cited Publications

Cat. No.: HY-125402

CAS No.: 1601496-05-2

Purity: 99.18%

Synonyms: GSK'843

Target:

RIP kinase Apoptosis

Research Areas:

Inflammation/Immunology

GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC₅₀ of 8.6 nM, and inhibits kinase activity with an IC₅₀ of 6.5 nM. GSK-843 can be used for the research of inflammation .

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4

HS-1371

4 Cited Publications

Cat. No.: HY-114349

CAS No.: 2158197-70-5

Purity: 99.89%

Target:

RIP kinase

Research Areas:

Cardiovascular Disease Cancer

HS-1371 is a potent and ATP-competitive receptor-interacting protein kinase 3 (RIP3) inhibitor with an IC₅₀ of 20.8 nM .

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3

GSK840

3 Cited Publications

Cat. No.: HY-104021

CAS No.: 2361146-30-5

Purity: 99.95%

Synonyms: GSK'840

Target:

RIP kinase

Research Areas:

Inflammation/Immunology

GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC₅₀ of 0.9 nM, and inhibits kinase activity with an IC₅₀ of 0.3 nM .

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2

Primidone

2 Cited Publications

Cat. No.: HY-B0339

CAS No.: 125-33-7

Target:

TRP Channel RIP kinase Sodium Channel GABA Receptor Necroptosis

Research Areas:

Neurological Disease Inflammation/Immunology

Primidone is the orally active inhibitor for TRPM3 (IC₅₀ = 0.6 μM), RIP kinase and voltage-gated sodium channel, and the antagonist for GABA receptor. Primidone can be used as the analgesic and anticonvulsant agent .

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