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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
81 Results for "
RNA helicase
" in MedChemExpress (MCE) Product Catalog:
Products (81)
81 Results for "RNA helicase" in MCE Product Catalog:
9
9 Publications Verification
Target:
Research Areas:
TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor . TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity .
7
7 Cited Publications
Target:
Research Areas:
RK-33 is an RNA helicase inhibitor against DDX3, and inhibits its helicase activity.
7
7 Cited Publications
Target:
Research Areas:
YK-4-279 blocks RNA Helicase A (RHA) binding with EWS-FLI1 (oncogenic protein). YK-4-279 induces apoptosis and shows anti-proliferation activities towards various cancer cells. YK-4-279 has a chiral center and it can be separated into two enantiomers. YK-4-279 can be used for the research of cancer .
1
1 Cited Publications
Target:
Research Areas:
DHX9-IN-1 is an inhibitor of ATP-dependent RNA helicase A (DHX9). Its EC50 value is 1.41 μM. DHX9-IN-1 has anti-tumor activity and can be used in colorectal cancer research .
1
1 Cited Publications
1
1 Cited Publications
Cat. No.: HY-P702583
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DDX5; DEAD (Asp-Glu-Ala-Asp) Box helicase 5; Prev. G17P1; Putative ATP-Dependent RNA helicase DDX5; Prev. HLR1; ATP-Dependent RNA helicase DDX5; Probable ATP-Dependent RNA helicase DDX5; RNA helicase; DEAD Box Protein 5; DEAD Box-5; P68; HUMP68; DEAD/H (A
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P703112
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DHX9; ATP-Dependent RNA helicase A; Prev. DDX9; NDH II; Prev. LKP; NDH2; Nuclear DNA helicase II; DEAH (Asp-Glu-Ala-His) Box Polypeptide 9; RNA helicase A; DEAH-Box helicase 9; Leukophysin; RNA helicase; RHA; MRD75; DEAD/H (Asp-Glu-Ala-Asp/His) Box Polype
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-164421
Target:
Research Areas:
PhpC is a G-quadruplex (G4)-DNA/RNA disruptor. PhpC disrupts DNA and RNA G4 structures and promotes G4 helicase activity. PhpC effectively enhancing the activity of Taq polymerase. PhpC modulates G-quadruplexs (G4s) both in vitro and in cells .
Synonyms: RX-5902
Target:
Research Areas:
Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase (P-p68) and a potent first-in-class anti-cancer agent. Supinoxin interacts with Y593 phosphorylated-p68 and attenuates the nuclear shuttling of β-catenin. Supinoxin induces cell apoptosis and inhibits growth of TNBC cancer cell lines with IC50s ranging from 10 nM to 20 nM .
Cat. No.: HY-160007
CAS No.: 2973401-57-7
Target:
Research Areas:
DHX9-IN-3 (Compound 621) is an inhibitor of ATP-dependent RNA helicase A (DHX9). DHX9-IN-3 has an IC50 of 8.7 nM for anti-proliferation in LS411N cells. DHX9-IN-3 can be used in the study of cancer .
Cat. No.: HY-160009
CAS No.: 2973398-17-1
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Research Areas:
DHX9-IN-5 (compound 277) is a RNA helicase DHX9 inhibitor with an IC50 of 4.3 nM .
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DHX9-IN-9 (509) is a RNA helicase DHX9 inhibitor, with an EC50 of 0.0177 μM in DHX9 cellular target engagement. Used in cancer research .
Cat. No.: HY-105387
CAS No.: 178182-49-5
Target:
Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth .
Cat. No.: HY-P5394
CAS No.: 288855-20-9
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Research Areas:
Cat. No.: HY-176268
Synonyms: RA-0188293; RA-NSP2-1
Research Areas:
SGC-NSP2hel-1 (RA-0188293), a chemical probe, is a potent, specific and orally active nsP2 inhibitor. SGC-NSP2hel-1 has broad spectrum activity against multiple alphaviruses of the nsP2 helicase with a CC50 > 250 μM.
SGC-NSP2hel-1 (RA-0188293) shows selectivity index > 4000 against human
RNA helicases. SGC-NSP2hel-1 reduces virus replication and limited virus-induced pathology by forming a stable complex with nsP2 and ATP in a preclinical small animal model of CHIKV disease.
Cat. No.: HY-122903S
CAS No.: 3034816-36-6
Cat. No.: HY-160008
CAS No.: 2973401-45-3
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Research Areas:
DHX9-IN-4 (Compound 609) is an ATP-dependent inhibitor of RNA helicase A (DHX9) with potential for cancer research .
Cat. No.: HY-160010
CAS No.: 2973401-56-6
Target:
Research Areas:
DHX9-IN-6 (Compound 620) is an ATP-dependent inhibitor of RNA helicase A (DHX9) with potential for cancer research .
Cat. No.: HY-157605
CAS No.: 2973402-91-2
Target:
Research Areas:
DHX9-IN-11 (469) is a RNA helicase DHX9 inhibitor, with an EC50 of 0.0838 μM in DHX9 cellular target engagement. Used in cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
