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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
42 Results for "
RNA methylation
" in MedChemExpress (MCE) Product Catalog:
Products (42)
42 Results for "RNA methylation" in MCE Product Catalog:
5
5 Cited Publications
Category:
Alkaloids Other Diseases Disease markers Endogenous metabolite Disease Research Fields Cervical Cancer Markers Cancer
Target:
3
3 Cited Publications
Cat. No.: HY-W037893
CAS No.: 122323-88-0
Synonyms: Methyl piperazine-2-carboxylate dihydrochloride; METTL3 activator-1
Research Areas:
CHMA1004 (Methyl piperazine-2-carboxylate; METTL3 activator-1) dihydrochloride is a METTL3/METTL14/WTAP methyltransferase complex activator. CHMA1004 dihydrochloride exhibits neuroprotective and anxiolytic potential by enhancing m 6A methylation modification of RNA. CHMA1004 dihydrochloride promotes HIV replication in an infection context. CHMA1004 dihydrochloride can be used in studies related to anxiety disorders and HIV-1 infection .
2
2 Cited Publications
Target:
Research Areas:
2
2 Cited Publications
Cat. No.: HY-W008091
CAS No.: 554-01-8
2
2 Cited Publications
Cat. No.: HY-W008091R
CAS No.: 554-01-8
2
2 Cited Publications
Cat. No.: HY-W008091A
CAS No.: 58366-64-6
Research Areas:
5-Methylcytosine hydrochloride is a well-characterized DNA modification in prokaryotes and eukaryotes. 5-Methylcytosine hydrochloride forms symmetrical methylation on CpG dinucleotides in DNA, stabilizes tRNA/rRNA structure in RNA, and affects mRNA translation. 5-Methylcytosine hydrochloride can be oxidized to generate 5hmC, 5fC, and 5caC. 5-Methylcytosine hydrochloride can be used in epigenetics, developmental biology, and the study of diseases such as colorectal cancer and hepatocellular carcinoma .
1
Category:
Infection Antibiotics Microorganism Disease Research Antibacterial Disease Research Fields Other Antibiotics
Target:
1
1 Cited Publications
Synonyms: N3-Methyluridine
Target:
1
1 Cited Publications
Cat. No.: HY-P1108
CAS No.: 681260-70-8
Target:
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1
1 Cited Publications
Cat. No.: HY-P1108A
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-P10387
1
1 Cited Publications
Target:
Research Areas:
DS-437 is a dual PRMT5/7 inhibitor (IC50s of PRMT5/7=6 μM). DS-437 is selective for PRMT5 and PRMT7 over 29 other human protein-, DNA-, and RNA-methyltransferases. DS-437 is a S-adenosylmethionine (SAM)-competitive inhibitor of PRMT5. DS-437 also inhibits DNMT3A and DNMT3B, with IC50s of 52 and 62 μM, respectively. DS-437 inhibits the methylation of FOXP3 .
1
1 Cited Publications
Cat. No.: HY-P10387A
Cat. No.: HY-P10272
CAS No.: 1628323-80-7
Synonyms: PTG-300
Target:
Research Areas:
Cat. No.: HY-178159
CAS No.: 2244341-81-7
Target:
Research Areas:
SA91-0178 is a METTL1 inhibitor. SA91-0178 inhibits m 7G methylation of RNA, reduces SARM1 stability, mitigates NAD + depletion and metabolic reprogramming in macrophages. SA91-0178 demonstrates excellent protective efficacy against multiple organ injury in cecal ligation and puncture (CLP)-induced and ischemia/reperfusion (I/R)-induced mice. SA91-0178 can be used for the study of systemic inflammatory diseases .
Synonyms: AT-752 free base
Research Areas:
Arbemnifosbuvir (AT-752 free base) is an orally active inhibitor of DENV NS5 RdRp and MTase, and is also a guanosine nucleotide analog prodrug. Arbemnifosbuvir forms the active triphosphate metabolite AT‑9010 (HY-139165) in peripheral blood mononuclear cells, which competes with GTP to terminate RNA synthesis and binds to the GTP/RNA-cap site to inhibit 2'-O-methylation. Arbemnifosbuvir reduces viremia, improves survival, prevents weight loss, and decreases viral load in a mouse model of dengue virus. Arbemnifosbuvir can be used for research related to viral infections .
Target:
Nucleoside Antimetabolite/Analog Drug Metabolite DNA Alkylator/Crosslinker DNA/RNA Synthesis
Research Areas:
6-Thioguanosine (6-Mercaptoguanosine) is a ribonucleoside (nucleotide) metabolite of Azathioprine (HY-B0256). 6-Thioguanosine forms TGTP, which binds to Rac1 GTPase in an inhibitory manner, and is incorporated into newly synthesized RNA, mRNA, large/small RNA, and genomic DNA, with mRNA being the most abundant. 6-Thioguanosine inhibits the methylation of adjacent cytosines at methylated CpG sites, enhances the methylation of contralateral cytosines at unmethylated CpG sites, and inhibits the synthesis of poly (A)-containing RNA. 6-Thioguanosine does not inhibit general protein synthesis, does not cause depolymerization of polyribosomes, does not affect cytoplasmic/nuclear RNA synthesis, and does not affect RNA lacking poly (A) in the cytoplasm. 6-Thioguanosine can be used in research on acute lymphoblastic leukemia .
Cat. No.: HY-113081R
CAS No.: 15763-06-1
Cat. No.: HY-N4031
CAS No.: 82375-29-9
Cat. No.: HY-W008091S
CAS No.: 1219795-15-9
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
