55

Baloxavir

55 Publications Verification

Cat. No.: HY-109025A

CAS No.: 1985605-59-1

Purity: 99.68%

Synonyms: Baloxavir acid; S-033447

Target:

Influenza Virus

Research Areas:

Infection Cancer

Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .

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47

Simeprevir

47 Cited Publications

Cat. No.: HY-10241

CAS No.: 923604-59-5

Purity: 98.79%

Synonyms: TMC435; TMC435350

Target:

HCV HCV Protease SARS-CoV DNA/RNA Synthesis

Research Areas:

Infection

Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K_i of 0.36 nM. Simeprevir inhibits HCV replication with an EC₅₀ of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (M ^pro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses .

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29

GS-441524

29 Cited Publications

Cat. No.: HY-103586

CAS No.: 1191237-69-0

Purity: 99.89%

Target:

DNA/RNA Synthesis SARS-CoV

Research Areas:

Infection

GS-441524 is a potent, orally active and CNS-penetrant viral RNA-dependent RNA polymerase inhibitor. GS-441524 competes with natural nucleosides to block viral RNA transcription as an alternative substrate and RNA chain terminator. GS-441524 inhibits the replication of feline infectious peritonitis virus, African swine fever virus, and severe acute respiratory syndrome coronavirus 2. GS-441524 reduces viral RNA levels in cats. GS-441524 can be used in research related to feline infectious peritonitis, African swine fever, and coronavirus disease 2019 (COVID-19) .

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29

GS-441524 hydrochloride

29 Cited Publications

Cat. No.: HY-103586A

CAS No.: 2378280-82-9

Target:

DNA/RNA Synthesis SARS-CoV

Research Areas:

Infection

GS-441524 hydrochloride is a potent, orally active and CNS-penetrant viral RNA-dependent RNA polymerase inhibitor. GS-441524 hydrochloride competes with natural nucleosides to block viral RNA transcription as an alternative substrate and RNA chain terminator. GS-441524 hydrochloride inhibits the replication of feline infectious peritonitis virus, African swine fever virus, and severe acute respiratory syndrome coronavirus 2. GS-441524 hydrochloride reduces viral RNA levels in cats. GS-441524 hydrochloride can be used in research related to feline infectious peritonitis, African swine fever, and coronavirus disease 2019 (COVID-19) .

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7

EIDD-2749

7 Cited Publications

Cat. No.: HY-146246

CAS No.: 1613589-24-4

Purity: 99.86%

Synonyms: 4'-FlU; 4'-Fluorouridine

Target:

RSV SARS-CoV HCV

Research Areas:

Infection

EIDD-2749 (4'-Fluorouridine) is an orally active RdRp inhibitor. EIDD-2749 effectively blocks the replication of RSV and SARS-CoV-2. EIDD-2749 also exhibits activity against HCV and lymphocytic choriomeningitis virus (LCMV). EIDD-2749 is a promising oral therapeutic candidate for COVID-19 and is also suitable for research on other RNA viruses .

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3

2'-C-Methyladenosine

3 Cited Publications

Cat. No.: HY-125371

CAS No.: 15397-12-3

Purity: 99.50%

Target:

HCV

Research Areas:

Infection Inflammation/Immunology

2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication. 2'-C-Methyladenosine inhibits HCV replicon and NS5B-catalyzed RNA synthesis with IC₅₀ values of 0.3μM and 1.9 μM, respectively. 2'-C-Methyladenosine also potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis .

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