55

Favipiravir

55 Publications Verification

Cat. No.: HY-14768

CAS No.: 259793-96-9

Purity: 99.97%

Synonyms: T-705

Target:

DNA/RNA Synthesis Influenza Virus SARS-CoV Bacterial

Research Areas:

Infection

Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC₅₀ of 341 nM.

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47

Simeprevir

47 Cited Publications

Cat. No.: HY-10241

CAS No.: 923604-59-5

Purity: 98.79%

Synonyms: TMC435; TMC435350

Target:

HCV HCV Protease SARS-CoV DNA/RNA Synthesis

Research Areas:

Infection

Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K_i of 0.36 nM. Simeprevir inhibits HCV replication with an EC₅₀ of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (M ^pro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses .

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29

GS-441524

29 Cited Publications

Cat. No.: HY-103586

CAS No.: 1191237-69-0

Purity: 99.89%

Target:

DNA/RNA Synthesis SARS-CoV

Research Areas:

Infection

GS-441524 is a potent, orally active and CNS-penetrant viral RNA-dependent RNA polymerase inhibitor. GS-441524 competes with natural nucleosides to block viral RNA transcription as an alternative substrate and RNA chain terminator. GS-441524 inhibits the replication of feline infectious peritonitis virus, African swine fever virus, and severe acute respiratory syndrome coronavirus 2. GS-441524 reduces viral RNA levels in cats. GS-441524 can be used in research related to feline infectious peritonitis, African swine fever, and coronavirus disease 2019 (COVID-19) .

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29

GS-441524 hydrochloride

29 Cited Publications

Cat. No.: HY-103586A

CAS No.: 2378280-82-9

Target:

DNA/RNA Synthesis SARS-CoV

Research Areas:

Infection

GS-441524 hydrochloride is a potent, orally active and CNS-penetrant viral RNA-dependent RNA polymerase inhibitor. GS-441524 hydrochloride competes with natural nucleosides to block viral RNA transcription as an alternative substrate and RNA chain terminator. GS-441524 hydrochloride inhibits the replication of feline infectious peritonitis virus, African swine fever virus, and severe acute respiratory syndrome coronavirus 2. GS-441524 hydrochloride reduces viral RNA levels in cats. GS-441524 hydrochloride can be used in research related to feline infectious peritonitis, African swine fever, and coronavirus disease 2019 (COVID-19) .

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27

Erythromycin

27 Cited Publications

Cat. No.: HY-B0220

CAS No.: 114-07-8

Category:

Disease Research Antibacterial Infection Microorganisms Macrolide Antibiotics Antibiotics Animal Husbandry Mammalian Cell Culture Anticancer Disease Research Fields

Target:

Bacterial Antibiotic DNA/RNA Synthesis

Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid ^[1][2]. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research ^[3][4].

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27

Erythromycin lactobionate

27 Cited Publications

Cat. No.: HY-B0220A

CAS No.: 3847-29-8

Target:

Antibiotic Bacterial DNA/RNA Synthesis

Research Areas:

Infection Cancer

Erythromycin lactobionate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin lactobionate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid ^[1][2]. Erythromycin lactobionate also exhibits antitumor and neuroprotective effect in different fields of research ^[3][4].

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27

Erythromycin thiocyanate

27 Cited Publications

Cat. No.: HY-B0220D

CAS No.: 7704-67-8

Category:

Infection Microorganisms Macrolide Antibiotics Antibiotics Disease Research Antibacterial Anticancer Disease Research Fields

Target:

Bacterial Antibiotic DNA/RNA Synthesis

Erythromycin thiocyanate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin thiocyanate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid ^[1][2]. Erythromycin thiocyanate also exhibits antitumor and neuroprotective effect in different fields of research ^[3][4].

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26

Dihydromyricetin

26 Cited Publications

Cat. No.: HY-N0112

CAS No.: 27200-12-0

Synonyms: Ampelopsin; Ampeloptin

Category:

Infection Flavanonols Flavonoids Phenols Polyphenols Plants Other Families Extract Disease Research Fields

Target:

mTOR Influenza Virus DNA/RNA Synthesis Autophagy

Dihydromyricetin is a potent inhibitor with an IC₅₀ of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 22 μM.

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23

Suramin sodium salt

23 Cited Publications

Cat. No.: HY-B0879A

CAS No.: 129-46-4

Synonyms: Suramin hexasodium salt

Target:

Phosphatase Sirtuin Reverse Transcriptase Topoisomerase SARS-CoV Parasite Apoptosis

Research Areas:

Infection Cardiovascular Disease Cancer

Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor . Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC₅₀=297 nM), SirT2 (IC₅₀=1.15 μM), and SirT5 (IC₅₀=22 μM) . Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC₅₀=5 μM) . Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor . Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent .

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