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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
RNF14
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "RNF14" in MCE Product Catalog:
Cat. No.: HY-W854844A
CAS No.: 3065021-33-9
Research Areas:
JP-2-196 (TFA) is a molecular glue handle that can bind to the E3-ubiquitin ligases (RNF126, LRSAM1, RNF40, MID2, and RNF14) in vitro. JP-2-196 (TFA) can be used to synthesize molecular glue degraders .
Cat. No.: HY-RS12052
Target:
Research Areas:
RNF14 Human Pre-designed siRNA Set A contains three designed siRNAs for RNF14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS21735
Target:
Research Areas:
Rnf14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rnf14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS28252
Target:
Research Areas:
Rnf14 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rnf14 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-177569
Research Areas:
NVS1.1 is an orally active, blood-brain barrier-penetrant eRF1 degrader. NVS1.1 induces ubiquitination of eRF1 at Lys279, mediates proteasomal degradation via the E3 ubiquitin ligases RNF14 and RNF25 as well as the translational stress sensor GCN1, traps eRF1 at the ribosomal A-site, inhibits translation termination and triggers ribosome collision. As a readthrough enhancer, NVS1.1 enables near-cognate tRNA incorporation at premature termination codons by reducing intracellular eRF1 levels. NVS1.1 activates ribosome-associated quality control pathways via ribosome collision, including ubiquitination of small subunit ribosomal proteins. NVS1.1 restores functional full-length CFTR and IDUA proteins and reduces glycosaminoglycan accumulation in relevant models. NVS1.1 can be used in the research of cystic fibrosis and Hurler syndrome (mucopolysaccharidosis type I, MPS I) .
Cat. No.: HY-177757
CAS No.: 1831092-94-4
Research Areas:
NVS2.1 is a potent, orally active and brain-penetrant readthrough promoter. NVS2.1 triggers the degradation of eRF1 by activating the ribosome-related quality control pathways (involving GCN1, RNF14, and RNF25), thereby facilitating the reading through of premature termination codons. NVS2.1 can be used for the research of genetic diseases caused by nonsense mutations .
Cat. No.: HY-W854844B
Research Areas:
JP-2-196 hydrochloride is a molecular glue that covalently targets the RING family E3 ligase RNF126. JP-2-196 hydrochloride also binds to RNF40, MID2, RNF219, RNF14, and LRSAM1. JP-2-196 hydrochloride induces the formation of ternary complexes between RNF126 and target proteins (e.g., BRD4, AR-V7), thereby promoting their ubiquitination and proteasomal degradation. JP-2-196 hydrochloride has potential for cancer research (such as prostate cancer and leukemia) .
Cat. No.: HY-P701558
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RNF14; RING Finger Protein 14; Ring Finger Protein 14; CDNA FLJ58064, Highly Similar To RING Finger Protein 14; ARA54; Androgen Receptor Associated Protein 54; HFB30; Androgen Receptor-Associated Protein 54; E3 Ubiquitin-Protein Ligase RNF14; RBR-Type E3
Species:
Human
Source:
E. coli
Cat. No.: HY-P701559
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RNF14; RING Finger Protein 14; Ring Finger Protein 14; CDNA FLJ58064, Highly Similar To RING Finger Protein 14; ARA54; Androgen Receptor Associated Protein 54; HFB30; Androgen Receptor-Associated Protein 54; E3 Ubiquitin-Protein Ligase RNF14; RBR-Type E3
Species:
Human
Source:
E. coli
Cat. No.: HY-W854844
CAS No.: 2913587-30-9
Research Areas:
JP-2-196 is a molecular glue that covalently targets the RING family E3 ligase RNF126. JP-2-196 also binds to RNF40, MID2, RNF219, RNF14, and LRSAM1. JP-2-196 induces the formation of ternary complexes between RNF126 and target proteins (e.g., BRD4, AR-V7), thereby promoting their ubiquitination and proteasomal degradation. JP-2-196 has potential for cancer research (such as prostate cancer and leukemia) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
