1 Result for "

RO-7227166

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "RO-7227166" in MCE Product Catalog:

Cat. No.: HY-P990017
CAS No.: 2417199-08-5
Synonyms: CD19-4-1BBL; RO7227166; RG6076
Target:  

CD19

Research Areas:  

Cancer

Englumafusp alfa (CD19-4-1BBL) is a 4-1BB ligand fusion protein targeting CD19. Englumafusp alfa binds human 4-1BB and CD19, crosslinks T cells into trimeric complexes, and resists internalization upon binding to CD19-positive B cells. Englumafusp alfa induces interferon-γ in activated peripheral blood mononuclear cells and promotes immune synapse formation with CD20-TCB. Englumafusp alfa can be used in research on relapsed or refractory B-cell non-Hodgkin lymphoma .
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