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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
ROCK1/2
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "ROCK1/2" in MCE Product Catalog:
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DJ4 is a ATP-competitive inhibitor of ROCK1/2 (IC50 values:5 and 50 nM) and MRCKα/β (IC50 values:10 and 100 nM). DJ4 blocks stress fiber formation and inhibits migration and invasion of cancer cells. DJ4 can be used for study of lung cancer, breast cancer, and pancreatic (PANC-1) cancer [1].
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1-Amino-2-methylpropan-2-ol is a primary amine and intermediate. 1-Amino-2-methylpropan-2-ol can be used in the synthesis of ROCK1/2 inhibitors [1] .
Cat. No.: HY-178122
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THNAN69 is a PROTAC degrader targeting LIMK2, which efficiently degrades ectopically expressed EGFP-LIMK2 in live HuCCT1 cells with a DC50 of 1 nM. THNAN69 induces isoform-specific ubiquitin-mediated degradation of LIMK2 by recruiting the CRBN E3 ligase, forming a stable ternary complex with LIMK2 and CRBN; this degradation process depends on the activity of cullin-RING ligase. THNAN69 does not reduce phosphorylated cofilin levels, as LIMK1 can compensate for the loss of LIMK2; it also stimulates compensatory activation of the Rho signaling pathway including PAK1/2 and ROCK1/2. THNAN69 serves as a selective chemical probe for dissecting the LIMK2 isoform-dependent biological mechanisms. THNAN69 can be used in the research of cholangiocellular carcinoma and acute lymphoblastic leukemia [1].
Cat. No.: HY-N15301
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Cat. No.: HY-33948S
CAS No.: 1953176-77-6
Synonyms: 1,1-Dimethylethanolamine-d6; 2-Amino-α,α-dimethylethanol-d6; 2-Hydroxy-2-methyl-1-propylamine-d6; 2-Hydroxy-2-methylpropan-1-amine-d6
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1-Amino-2-methylpropan-2-ol-d6 (1,1-Dimethylethanolamine-d6) is the d6-labeled 1-Amino-2-methylpropan-2-ol (HY-33948). 1-Amino-2-methylpropan-2-ol is a primary amine and intermediate. 1-Amino-2-methylpropan-2-ol can be used in the synthesis of ROCK1/2 inhibitors [1] .
Cat. No.: HY-168650
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ROCK/HDAC-IN-1 (Compound 10h) is an orally active ROCK/HDAC inhibitor. ROCK/HDAC-IN-1 inhibits ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). ROCK/HDAC-IN-1 stimulates the activation of DAMPs, specifically Calreticulin (CRT) exposure and HMGB1 release, indicating that it is a potential ICD inducer.. ROCK/HDAC-IN-1 has antiproliferative activity against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cell), and inhibits tumor growth and activates T cells without apparent toxicity [1].
Cat. No.: HY-N15301A
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
