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53 Results for "

RSK1

" in MedChemExpress (MCE) Product Catalog:

Products (53)

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Prexasertib

40 Publications Verification

Cat. No.: HY-18174

CAS No.: 1234015-52-1

Synonyms: LY2606368

Target:

Checkpoint Kinase (Chk) Apoptosis

Research Areas:

Cancer

Prexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib inhibits CHK2 (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib shows potent anti-tumor activity ^[1] .

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Prexasertib dihydrochloride

40 Publications Verification

Cat. No.: HY-18174A

CAS No.: 1234015-54-3

Synonyms: LY2606368 dihydrochloride

Target:

Checkpoint Kinase (Chk) Apoptosis

Research Areas:

Cancer

Prexasertib dihydrochloride (LY2606368 dihydrochloride) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib dihydrochloride inhibits CHK2 (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib dihydrochloride causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib dihydrochloride shows potent anti-tumor activity ^[1] .

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Prexasertib dimesylate

40 Publications Verification

Cat. No.: HY-18174E

CAS No.: 1234015-58-7

Synonyms: LY2606368 dimesylate

Target:

Checkpoint Kinase (Chk) Apoptosis

Research Areas:

Cancer

Prexasertib dimesylate (LY2606368 dimesylate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib dimesylate inhibits CHK2 (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib dimesylate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib dimesylate shows potent anti-tumor activity ^[1] .

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Temuterkib

39 Cited Publications

Cat. No.: HY-101494

CAS No.: 1951483-29-6

Purity: 99.94%

Synonyms: LY3214996

Target:

ERK

Research Areas:

Cancer

Temuterkib (LY3214996) is a highly selective inhibitor of ERK1 and ERK2, with IC₅₀ of 5 nM for both enzymes in biochemical assays. Temuterkib potently inhibits cellular p-RSK1 in BRAF and RAS mutant cancer cell lines. Temuterkib shows potent antitumor activities in cancer models with MAPK pathway alterations.

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BI-D1870

23 Cited Publications

Cat. No.: HY-10510

CAS No.: 501437-28-1

Purity: 99.43%

Target:

Ribosomal S6 Kinase (RSK) Autophagy

Research Areas:

Cancer

BI-D1870 is an ATP-competitive, cell permeable and brain penetrated inhibitor of RSK isoforms, with IC₅₀s of 31 nM/24 nM/18 nM/15 nM for RSK1/RSK2/RSK3/RSK4, respectively ^[1] .

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