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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
RT polymerase activity
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "RT polymerase activity" in MCE Product Catalog:
Cat. No.: HY-146365
CAS No.: 2132412-77-0
Target:
Research Areas:
HIV-1 inhibitor-30 (compound 10i) is a potent HIV-1 inhibitor with an EC50 value of 40 nM and an IC50 value of 80 nM for HIV-1 RT DNA polymerase. HIV-1 inhibitor-30 has highly antiretroviral activity against seven non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV-1 strains (RT-K103N; RT-Y181C; RT-K103N,Y181C; RT-L100I,K103N; RT-Y188L; RT-K103N,G190A; RT-K103N,V108I) with IC50s of 0.04~1.42 μM. HIV-1 inhibitor-30 can be used for researching AIDS .
Cat. No.: HY-185449
CAS No.: 1909302-89-1
Research Areas:
HIV RT-IN-2 is a HIV reverse transcriptase inhibitor with an IC50 value of 1.2 μM for HIV-1 RT RNA-dependent DNA polymerase. HIV RT-IN-2 potently inhibits all three modes of HIV-1 RT-associated RNase H activity (internal, 3'-DNA directed, 5'-RNA directed cleavage) and inhibits HIV-1 replication. HIV RT-IN-2 can be used for the research of HIV-1 infection .
Cat. No.: HY-189657
Target:
Research Areas:
NNRT-IN-18 is an orally active HIV-1 non-nucleoside reverse transcriptase (NNRT) inhibitor with broad-spectrum anti-HIV-1 activity. NNRT-IN-18 binds to the allosteric non-nucleoside inhibitor binding pocket and inhibits RT polymerase activity with an IC50 of 0.259 μM. NNRT-IN-18 exhibits low cytotoxicity and a high selectivity index, and shows minimal inhibitory activity against major cytochrome P450 isoforms. NNRT-IN-18 retains activity against NNRTI-resistant HIV-1 mutant strains. NNRT-IN-18 can be used for research on HIV-1 infection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
