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38 Results for "

RTA

" in MedChemExpress (MCE) Product Catalog:

Products (38)

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Bardoxolone methyl

44 Publications Verification

Cat. No.: HY-13324

CAS No.: 218600-53-4

Purity: 98.92%

Synonyms: RTA 402; NSC 713200; CDDO Methyl ester

Target:

Keap1-Nrf2 SARS-CoV Virus Protease

Research Areas:

Infection Neurological Disease Inflammation/Immunology

Bardoxolone methyl (RTA 402) is an orally active and blood-brain-barrier-penetrant activator of Nrf2 and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone methyl inhibits SARS-CoV-2 replication in Vero cells with an EC₅₀ value of 0.29 μM. Bardoxolone methyl increases levels of pNrf2 and HO-1, inhibits inflammatory mediators like pNFκB and MCP-1. Bardoxolone methyl activates the Nrf2 pathway to enhance antioxidant and anti-inflammatory responses, inhibits viral replication, and improves mitochondrial function. Bardoxolone methyl can be used in research on chemotherapy-induced neuropathic pain (CINP), COVID-19, and chronic kidney disease (CKD) .

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Omaveloxolone

29 Cited Publications

Cat. No.: HY-12212

CAS No.: 1474034-05-3

Purity: 99.38%

Synonyms: RTA 408

Target:

Keap1-Nrf2 STING Apoptosis

Research Areas:

Inflammation/Immunology Cancer

Omaveloxolone (RTA 408) is an antioxidant inflammation modulator (AIM), which activates Nrf2 and suppresses nitric oxide (NO). Omaveloxolone attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling.

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Bardoxolone

25 Cited Publications

Cat. No.: HY-14909

CAS No.: 218600-44-3

Purity: 99.50%

Synonyms: CDDO; RTA 401

Target:

Keap1-Nrf2 NF-κB SARS-CoV Apoptosis Reactive Oxygen Species (ROS) Glutathione Peroxidase Necroptosis

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Bardoxolone (CDDO; RTA 401) is a Nrf2 activator. Bardoxolone shows anti-SARS-CoV-2 3CLpro with IC50 of 27.99 μM. Bardoxolone activates the Nrf2 pathway and inhibits the NF-κB pathway. Bardoxolone can induce cells differentiation, apoptosis and shows antiproliferative activity against cancer cells. Bardoxolone can increase ROS and decrease intracellular GSH levels. Bardoxolone inhibits Z-VAD-FMK (HY-16658B)-induced necroptosis. Bardoxolone can be used for the research of cancer, inflammation and infection, such as SARS-CoV infection and glioblastoma .

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