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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
RUVBL1/2 complex
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "RUVBL1/2 complex" in MCE Product Catalog:
17
17 Cited Publications
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CB-6644 is a selective inhibitor of RUVBL1/2 complex with anti-cancer activity. CB-6644 blocks the ATPase activity of RUVBL1/2 with an IC50 of 15 nM .
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RUVBL1/2 ATPase-IN-1 is an ATPase inhibitor targeting the RUVBL1/2 complex, with an IC50 of 6.0 μM. RUVBL1/2 ATPase-IN-1 inhibits RUVBL1 ATPase activity, with a human IC50 of 7.7 μM. RUVBL1/2 ATPase-IN-1 exerts antiproliferative/cytotoxic effects in cancer cell lines. RUVBL1/2 ATPase-IN-1 can be used for cancer research .
Cat. No.: HY-183643
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RUVBL1/2-IN-1 is an orally active RUVBL1/2 complex inhibitor with an EC50 of 0.012 μM against human targets. RUVBL1/2-IN-1 impairs ATPase-related functions, thereby reducing nuclear MYC protein levels, impairing DNA damage response and inhibiting cancer cell proliferation. In a MYC-dependent Burkitt's lymphoma xenograft model, RUVBL1/2-IN-1 effectively inhibits tumor growth and suppresses the activity of RUVBL1 R117H mutant cells. RUVBL1/2-IN-1 has been applied in research related to MYC-dependent Burkitt's lymphoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
