4 Results for "

Rhamnocitrin

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "Rhamnocitrin" in MCE Product Catalog:

4
Rhamnocitrin
Rhamnocitrin
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4 Cited Publications
Cat. No.: HY-N1353
CAS No.: 569-92-6
Category:  

Cardiovascular Disease Flavonols Flavonoids Phenols Polyphenols Plants Other Families Extract Disease Research Fields

Target:  

Free Radical Scavengers p38 MAPK

Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3 and MAPK pathways and can scavenge DPPH (IC50=28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6, IL-8) and adhesion molecules (such as ICAM-1, VCAM-1). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells) .
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Rhamnocitrin 3-glucoside
Rhamnocitrin 3-glucoside
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Cat. No.: HY-N11472
CAS No.: 41545-37-3
Synonyms: Rhamnocitrin-3-O-β-D-glucopyranoside
Category:  

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