1

1 Cited Publications

Target:

Research Areas:

S7 is an inhibitory polypeptide targeting IL-6R, which specifically binds to IL-6R and its A chain (gp80/IL-6RA) to block its signal transduction. S7 inhibits IL-6-mediated anti-apoptosis (apoptosis), angiogenesis and the expression of VEGF-A, blocks related survival signaling pathways, and enhances the sensitivity of cancer cells to chemotherapeutic drugs. S7 can be applied to the research of related diseases such as cervical cancer, multiple myeloma, Kaposi's sarcoma, prostate cancer and basal cell carcinoma .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

43

Necrostatin 2 racemate

43 Publications Verification

Cat. No.: HY-14622A

CAS No.: 852391-15-2

Purity: 99.65%

Synonyms: Necrostatin 1S; Nec-1S; 7-Cl-O-Nec1

Target:

RIP kinase

Research Areas:

Cancer

Necrostatin 2 racemate (Nec-1S), the Necrostatin-1 (HY-15760) stable, is a potent and specific RIPK1 inhibitor lacking the IDO-targeting effect .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

5

c-Fos Antibody

5 Cited Publications

Cat. No.: HY-P80616

Synonyms: FOS; G0S7; Proto-oncogene c-Fos; Cellular oncogene fos; G0/G1 switch regulatory protein 7

Host:

Rabbit

Application:

WB, IHC-P, ICC/IF, ELISA

Reactivity:

Human, Mouse, Rat

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

3

c-Fos Antibody (YA506)

3 Cited Publications

Cat. No.: HY-P80081

Synonyms: G0S7, FOS, Protein c-Fos, Cellular oncogene fos, G0/G1 switch regulatory protein 7, Proto-oncogene c-Fos, Transcription factor AP-1 subunit c-Fos

Host:

Rabbit

Application:

WB, IHC-P, ICC/IF

Reactivity:

Human, Rat

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

SecinH3

1 Cited Publications

Cat. No.: HY-100559

CAS No.: 853625-60-2

Purity: 99.70%

Target:

Apoptosis

Research Areas:

Metabolic Disease Endocrinology Cancer

SecinH3 is an antagonist of cytohesins with IC₅₀s of 5.4 μM, 2.4 μM, 5.4 μM, 5.6 μM, 5.6 μM and 65 μM for hCyh1, hCyh2, mCyh3, hCyh3, drosophila steppke and yGea2-S7, respectively.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Ofirnoflastum

Cat. No.: HY-159520

CAS No.: 2731294-23-6

Synonyms: Ofirnoflast; HT-6184

Target:

NEKs NOD-like Receptor (NLR) Caspase Apoptosis Pyroptosis NF-κB

Research Areas:

Cardiovascular Disease Inflammation/Immunology Cancer

Ofirnoflastum (Ofirnoflast) is an orally active first-in-class allosteric NEK7 inhibitor with an IC₅₀ of 46 nM. Ofirnoflastum binds an allosteric site adjacent to NEK7’s ATP-binding pocket, induces conformational shifts, disrupts NEK7-NLRP3 binding, blocks NLRP3 inflammasome assembly, spares NEK7’s physiological functions, and suppresses caspase-1, caspase-8, NF-κB, and TNF activity. Ofirnoflastum reduces pro-inflammatory cytokine production, suppresses ASC specks, IL-1β release, pyroptotic cell death, and leukemic burden, induces apoptosis and erythroid differentiation, restores hematopoiesis, and improves outcomes in colitis models. Ofirnoflastum can be used for the research of myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

((2S,7aS)-2-Fluorohexahydro-1H-pyrrolizin-7a-yl)methanol

Cat. No.: HY-W106164A

CAS No.: 2820537-15-1

Target:

Drug Intermediate

Research Areas:

Others

((2S,7aS)-2-Fluorohexahydro-1H-pyrrolizin-7a-yl)methanol is a drug intermediate for synthesis of various active compounds.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

S-(-)-7-Desmethyl-8-nitro blebbistatin

Cat. No.: HY-133885

CAS No.: 856925-75-2

S-(-)-7-Desmethyl-8-nitro blebbistatin (compound 12) is an analog of (-)-Blebbistatin (HY-13441). (-)-Blebbistatin is a selective non-muscle myosin II inhibitor .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

(2S,3R,5S)-7-Deaza-2'-deoxy-7-iodoadenosine

Cat. No.: HY-W091788

CAS No.: 908130-61-0

Target:

Nucleoside Antimetabolite/Analog

Research Areas:

Others

(2S,3R,5S)-7-Deaza-2'-deoxy-7-iodoadenosine is the isomer of 7-Deaza-2'-deoxy-7-iodoadenosine (HY-W048490), and can be used as an experimental control. 7-Deaza-2'-deoxy-7-iodoadenosine is a modified oligonucleotide containing 7-Deazaadenine .

Compare

loading...