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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
270 Results for "
S-4
" in MedChemExpress (MCE) Product Catalog:
Products (270)
270 Results for "S-4" in MCE Product Catalog:
6
6 Publications Verification
Cat. No.: HY-P990679
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4
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GTx-007 (S-4) is an orally active and selective nonsteroidal androgen receptor (AR) modulator (SARM) and a partial agonist, with Ki of 4 nM. GTx-007 (S-4) is identified as SARMs with potent and tissue-selective in vivo pharmacological activity .
3
3 Cited Publications
Synonyms: (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid
Category:
Alkaloids Immune System Disorder Pyrrole Alkaloids Other Diseases Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields
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3
3 Cited Publications
Cat. No.: HY-163316
CAS No.: 3030697-87-8
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SIRT4-IN-1 is a selective and potent Sirtuin 4 (Sirt4) inhibitor with an IC50 of 16 μM for hSirt4. SIRT4-IN-1 also inhibits hSirt1, hSirt2, hSirt3, hSirt4 and hSirt6. SIRT4-IN-1 competes with acyl peptide substrate for Sirt4's acyl binding site, and is noncompetitive with NAD +. SIRT4-IN-1 increases glutamate dehydrogenase (GDH) activity and rescues pyruvate dehydrogenase (PDH) activity. SIRT4-IN-1 inhibits adipocyte differentiation and suppresses Sirt4 overexpression-induced increased differentiation. SIRT4-IN-1 can be used for the researches of cancer and metabolic disease .
2
2 Cited Publications
Synonyms: (S)-Cycloserine; (S)-4-Amino-3-isoxazolidone
Category:
Microorganisms Neurological Disease Antibiotics Disease Research Antibacterial Disease Research Fields Other Antibiotics Cancer
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2
2 Cited Publications
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CAIX Inhibitor S4 is a potent and selective inhibitor of carbonic anhydrase IX/XII (CA IX/XII), with a Ki of 7 nM and 2 nM, respectively. CAIX Inhibitor S4 also inhibits CA II and CA I (Ki=546 and 5600 nM, respectively). CAIX Inhibitor S4 can inhibit the number of lung metastasis in orthotopic MDA-MB-231 mouse model without affecting primary tumor growth .
1
1 Cited Publications
Cat. No.: HY-W011927S
CAS No.: 2483831-28-1
Synonyms: Bisphenol S (4,4'-Sulfonyldiphenol)-d8
1
1 Cited Publications
Cat. No.: HY-B0105B
CAS No.: 142128-57-2
Synonyms: (-)-Ketoconazole; (-)-Ketoconazol; (-)-R 41400
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Levoketoconazole ((-)-Ketoconazole) is the 2S,4R enantiomer derived from racemic Ketoconazole (HY-B0105). Levoketoconazole is a potent and orally active cortisol synthesis inhibitor. Levoketoconazole inhibits key steps in cortisol and testosterone synthesis by inhibiting CYP11B1, CYP11A1, and CYP17A1. Levoketoconazole can be used for research on endogenous Cushing’s syndrome .
1
1 Cited Publications
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KH-4-43 is an inhibitor of E3 CRL4. KH-4-43 inhibits E3 CRL4's core ligase complex and exhibits anticancer activity. KH-4-43 has a binding Kd to E3 ROC1-CUL4A CTD or the highly related ROC1-CUL1 CTD at 83 nM or 9.4 μM, respectively .
Synonyms: (2S,4R)-R-63373
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(2S,4R)-Hydroxy Itraconazole ((2S,4R)-R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
Cat. No.: HY-W007573
CAS No.: 34582-32-6
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Cat. No.: HY-41882
CAS No.: 90719-32-7
Synonyms: (-)-4-Benzyl-2-oxazolidinone
Cat. No.: HY-40354C
CAS No.: 1092578-47-6
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(3S,4S)-Tofacitinib is the less active S-enantiomer of Tofacitinib. Tofacitinib inhibits JAK3 with IC50 of 1 nM.
Cat. No.: HY-111532B
Purity: 98.15%
Target:
(3S,4S)-A2-32-01 (compound 24 (S,S)) is the low/inactive (S,S)-enantiomer of A2-32-01. A2-32-01 is a potent caseinolytic protease (ClpP) inhibitor. (3S,4S)-A2-32-01 is applicable for oncology and microbiology research .
Synonyms: SAF312; Vanilloid receptor antagonist 1
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Libvatrep (SAF312) is a non-competitive TRPV1 antagonist with an IC50 of 0.35-0.69 µM in HEK293T cells. It binds to the vanilloid pocket and an allosteric site, preventing S4/S5 conformational changes and channel opening. Libvatrep can be used for research on ocular surface pain and eye pain after photorefractive keratectomy [4].
Cat. No.: HY-P990796
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Cat. No.: HY-N8115
CAS No.: 129636-38-0
Category:
Monophenols Orchidaceae Extract Gastrodia elata Bl. Ketones, Aldehydes, Acids Phenols Plants
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Cat. No.: HY-123414
CAS No.: 1235406-09-3
Synonyms: PF-05196233
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GX-936 (PF-05196233) is a selective Nav1.7 inhibitor. GX-936 binds to the activated VSD4, forms a bidentate salt bridge with the R4 of the S4 helix, traps VSD4 in the activated state, and prevents the channel from recovering from the inactivated state. GX-936 can be used in studies related to pain .
Cat. No.: HY-W002062
CAS No.: 17016-83-0
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
