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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
SBDS
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "SBDS" in MCE Product Catalog:
Cat. No.: HY-168535
CAS No.: 1010913-79-7
Target:
Research Areas:
SJ6145 is a potent ligand for KLHDC2 SBD, with the Kd of 16.9 μM in SPR test, IC50 value of 42 μM in inhibiting KLHDC2 SBD binding to a di-Gly degron peptide test .
Cat. No.: HY-RS12463
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Research Areas:
SBDS Human Pre-designed siRNA Set A contains three designed siRNAs for SBDS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18499
Target:
Research Areas:
Sbds Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sbds gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24981
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Research Areas:
Sbds Rat Pre-designed siRNA Set A contains three designed siRNAs for Sbds gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P74570
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SBDS; SDS; SBDS Ribosome Maturation Factor; SBDS, Ribosome Assembly Guanine Nucleotide Exchange Factor; Ribosome Maturation Protein SBDS; FLJ10917; CGI-97; Shwachman-Bodian-Diamond Syndrome Isoform 3; SDO1; Shwachman-Bodian-Diamond Syndrome Protein; SWDS
Species:
Human
Source:
E. coli
Cat. No.: HY-P76049
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SBDS; SDS; SBDS Ribosome Maturation Factor; SBDS, Ribosome Assembly Guanine Nucleotide Exchange Factor; Ribosome Maturation Protein SBDS; FLJ10917; CGI-97; Shwachman-Bodian-Diamond Syndrome Isoform 3; SDO1; Shwachman-Bodian-Diamond Syndrome Protein; SWDS
Species:
Mouse
Source:
E. coli
Cat. No.: HY-D2939
CAS No.: 1622078-12-9
Cat. No.: HY-D3441
Target:
Research Areas:
LumiPK is an environment-sensitive probe that specifically targets the liver isoform of pyruvate kinase (PKL). LumiPK exhibits high affinity for PKL with a Kd of 37 nM. LumiPK integrates the 4-sulfonamido-7-aminobenzoxadiazole (SBD) fluorophore into a phthalazine scaffold, and its fluorescence intensity changes with the polarity of the chemical environment, thereby directly reflecting protein occupancy. LumiPK binds only to the tetrameric form of PKL, with the binding site being an allosteric pocket formed at the subunit interface, and key water-mediated interactions enhance its potency; in polar environments such as buffer, its fluorescence is significantly quenched, whereas upon binding to the nonpolar allosteric pocket of PKL, its fluorescence is enhanced. In fluorescence detection, its excitation/emission wavelengths are Ex/Em = 450/550 nm .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
