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35 Results for "

SGK1

" in MedChemExpress (MCE) Product Catalog:

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GSK 650394

30 Publications Verification

Cat. No.: HY-15192

CAS No.: 890842-28-1

Purity: 99.76%

Target:

SGK Influenza Virus

Research Areas:

Infection Cancer

GSK 650394 is a novel SGK inhibitor with IC₅₀ of 62 nM and 103 nM for SGK1 and SGK2 in the SPA assay respectively. GSK 650394 also inhibits influenza virus replication.

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August 31

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EMD638683

18 Cited Publications

Cat. No.: HY-15193

CAS No.: 1181770-72-8

Purity: 99.94%

Target:

SGK NOD-like Receptor (NLR) Interleukin Related Apoptosis

Research Areas:

Cardiovascular Disease Cancer

EMD638683 is an orally active SGK1 inhibitor with an IC₅₀ of 3 μM. EMD638683 exhibits strong inhibition against SGK1, moderate inhibition against SGK2 and SGK3, and shows excellent selectivity for other AGC kinase family members. EMD638683 has antihypertensive activity by inhibiting SGK1, and independently of the blood pressure-lowering effect, it effectively prevents heart inflammation and fibrosis caused by hypertension by inhibiting the cardiac NLRP3 inflammation body/ IL-1β axis. EMD638683 promotes apoptosis of colon cancer cells and sensitizes radiotherapy. EMD638683 (S-Form) can be used in research related to hypertension, hypertensive heart damage, and colon cancer ^[1] .

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