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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
SIRT2 binding pocket
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "SIRT2 binding pocket" in MCE Product Catalog:
Cat. No.: HY-113717
CAS No.: 1060430-64-9
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ICL-SIRT078 is a substrate-competitive SIRT2 deacylase/deacetylase inhibitor (human SIRT2 IC50 = 0.17-3.96 μM; Ki = 0.62 μM). ICL-SIRT078 acts by binding to the acetyl-lysine pocket and is selective for SIRT2 over other sirtuin isoforms. ICL-SIRT078 induces α-tubulin (α-Tubulin) hyperacetylation and FOXO3a accumulation in breast cancer cells, inhibits cell proliferation, and exerts neuroprotective effects against neuronal cell death in Parkinson's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
