2 Results for "

SIRT6 modulator

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "SIRT6 modulator" in MCE Product Catalog:

7
7 Cited Publications
Cat. No.: HY-N0010
CAS No.: 27741-01-1
Geniposidic acid is an orally active FXR modulator and SIRT6 activator. Geniposidic acid binds to the Ser332 and His447 sites on the FXR ligand-binding domain, thereby driving nuclear translocation, coactivator recruitment, and transcription of downstream bile acid and cholesterol metabolism-related genes. Geniposidic acid improves metabolic dysfunction-related fatty liver disease by activating the SIRT6 signaling pathway. Geniposidic acid inhibits inflammation and modulates gut microbiota to alleviate colitis. Geniposidic acid can be used in research on drug-induced liver injury, inflammatory bowel disease, metabolic dysfunction-related fatty liver disease, and metabolic dysfunction-related steatohepatitis .
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Cat. No.: HY-186009
CAS No.: 339156-78-4
Target:  

Sirtuin

Research Areas:  

Neurological Disease

SIRT6 modulator-1 is a SIRT6 modulator.
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