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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
29 Results for "
SK1
" in MedChemExpress (MCE) Product Catalog:
Products (29)
29 Results for "SK1" in MCE Product Catalog:
2
2 Cited Publications
Target:
Research Areas:
NS8593 hydrochloride is a potent and selective small conductance Ca 2+-activated K + channels (SK channels) inhibitor. NS8593 hydrochloride reversibly inhibits SK3-mediated currents with a Kd value of 77 nM. NS8593 hydrochloride inhibits all the SK1-3 subtypes Ca 2+-dependently (Kds of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca 2+), and does not affect the Ca 2+-activated K + channels of intermediate and large conductance (hIK and hBK channels, respectively) [1] .
2
2 Cited Publications
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Research Areas:
SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 58 nM.
1
SK1-I (BML-258), an analog of sphingosine, is an isozyme-specific competitive SPHK1 inhibitor with a Ki value of 10 μM [1]. SK1-I shows no activity at SPHK1 PKCα, PKCδ, PKA, AKT1, ERK1, EGFR, CDK2, IKKβ or CamK2β. SK1-I enhances autophagy and has antitumor activity .
Cat. No.: HY-137952
CAS No.: 875755-39-8
Target:
Research Areas:
NS8593 is an SK channel (small conductance Ca 2+-activated K+ channels) inhibitor. NS8593 reversibly inhibited recombinant SK3-mediated currents (human SK3 and rat SK3). NS8593 inhibits all the SK1-3 subtypes Ca 2+-dependently (Kd = 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca 2+). NS8593 does not affect the Ca 2+-activated K channels of intermediate and large conductance (hlk and hBK channels, respectively). NS8593 can also inhibit TRPM7 (melastatin-related TRP cation channel 7) (IC50 = 1.6 mM). NS8593 can be used for the study of central nervous system (CNS) related diseases [1] .
Cat. No.: HY-112485
CAS No.: 1142015-25-5
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Research Areas:
(R)-FTY720-vinylphosphonate is a sphingosine kinase 1 (SK1) inhibitor. (R)-FTY720-ene-phosphonate is also an FTY720 analogue. (R)-FTY720-vinylphosphonate is promising for research of solid tumors like breast cancer [1].
Cat. No.: HY-12900
CAS No.: 1425049-20-2
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RB-005 is a selective inhibitor of sphingosine kinase 1 (SK1) (IC50=3.6 µM), with weaker inhibition of another isoenzyme, SK2. The selective inhibition of RB-005 helps to distinguish the biological functions and roles of SK1 and SK2, which can be used in the study of inflammatory diseases and cancer [1].
Cat. No.: HY-101805R
CAS No.: 1218816-71-7
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SK1-IN-1 (Standard) is the analytical standard of SK1-IN-1 (HY-101805). This product is intended for research and analytical applications. SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 58 nM.
Cat. No.: HY-P702765
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SPHK1; SK 1; Sphingosine Kinase 1; Sphingosine Kinase; SPHK; SPHK1 Protein; Acetyltransferase SPHK1; SK1; SPK 1; SPK
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-124368
CAS No.: 1491909-40-0
Target:
Research Areas:
RB-042 is a SK1 and SK2 inhibitor with IC50 values of 5.3 μM and 5.0 μM, respectively. RB-042 is applicable to the research of inflammatory diseases [1] .
Cat. No.: HY-112385
CAS No.: 917236-13-6
ABC294735 is an orally active SK1/SK2 inhibitor. Combination of ABC294735 with Sorafenib (HY-10201) reduces pERK. ABC294735 exhibits anticancer activity against pancreatic adenocarcinoma and renal cell carcinoma. ABC294735 can be used in research related to pancreatic adenocarcinoma and renal cell carcinoma [1].
Cat. No.: HY-RS10030
Target:
Research Areas:
PAPSS1 Human Pre-designed siRNA Set A contains three designed siRNAs for PAPSS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS13665
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Research Areas:
Sphk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sphk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS07169
Target:
Research Areas:
KCNN1 Human Pre-designed siRNA Set A contains three designed siRNAs for KCNN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P8F004A
Synonyms: CD8,CD8-FITC,SK1
Cat. No.: HY-P8F004C
Synonyms: CD8,CD8-PE,SK1
Cat. No.: HY-P8F004F
Synonyms: CD8,CD8-PerCP,SK1
Cat. No.: HY-P8F004I
Synonyms: CD8,CD8-APC,SK1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
