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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
SR12460
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "SR12460" in MCE Product Catalog:
Cat. No.: HY-124578
CAS No.: 2055101-66-9
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SR12460 is a NEMO-binding domain mimetic and an inhibitor of the IKKβ-NEMO complex with an IC50 of 11.34 μM. SR12460 disrupts the IKKβ-NEMO interaction, thereby inhibiting NF-κB activation, including TNF-α- and LPS-induced NF-κB activation. SR12460 inhibits LPS-induced acute lung inflammation in mice and alleviates inflammatory infiltration, necrosis, and muscle degeneration in a mouse model of Duchenne muscular dystrophy. SR12460 is used for research on acute lung inflammation and Duchenne muscular dystrophy .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
