12

FKBP12 PROTAC dTAG-13

12 Publications Verification

Cat. No.: HY-114421

CAS No.: 2064175-41-1

Purity: 99.89%

Synonyms: dTAG-13

Target:

PROTACs FKBP Pregnane X Receptor (PXR)

Research Areas:

Cancer

FKBP12 PROTAC dTAG-13 (dTAG-13) is a FKBP12 ^F36V PROTAC degrader and a PXR partial agonist. FKBP12 PROTAC dTAG-13 induces ubiquitination and proteasomal degradation of proteins tagged with FKBP12 ^F36V, without degrading wild-type FKBP12 or un-fused PXR. It weakly promotes the recruitment of SRC-1, strongly inhibits the interaction between NCoR and PXR, and upregulates the expression of CYP3A4 and other drug metabolism-related genes. FKBP12 PROTAC dTAG-13 is applicable to research related to breast cancer and leukemia ^[1] .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

7

eCF506

7 Cited Publications

Cat. No.: HY-112096

CAS No.: 1914078-41-3

Purity: 99.17%

Synonyms: NXP900

Target:

Src

Research Areas:

Cancer

eCF506 (NXP900) is a highly potent and orally active YES1/SRC kinase inhibitor with an IC₅₀ of 0.47 nM. eCF506 locks its target into its native “closed” conformation, thereby inhibiting both kinase activity and complex formation with protein partners. eCF506 can be used for the study of esophageal squamous cancer and breast cancer ^[1].

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

GSK3987

2 Cited Publications

Cat. No.: HY-123402

CAS No.: 264206-85-1

Purity: 99.19%

Target:

LXR

Research Areas:

Metabolic Disease

GSK3987 is a pan LXRα/β agonist with EC₅₀s of 50 nM, 40 nM for LXRα-SRC1 and LXRβ-SRC1, respectively. GSK3987 increases the expression of ABCA1 and SREBP-1c. GSK3987 induces cellular cholesterol efflux and triglyceride accumulation ^[1].

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

Tanaproget

1 Cited Publications

Cat. No.: HY-15606

CAS No.: 304853-42-7

Purity: 99.87%

Synonyms: NSP-989

Target:

Progesterone Receptor

Research Areas:

Endocrinology

Tanaproget is an orally effective, selective nonsteroidal progesterone receptor (PR) agonist targeting human PR with an IC₅₀ of 1.7 nM. Tanaproget promotes the interaction between PR receptors and coactivators (such as SRC-1), thereby inhibiting the secretion of matrix metalloproteinases (MMP-3/MMP-7) and reducing endometrial tissue invasion and angiogenesis. Tanaproget can be used for contraception and endometriosis inhibition research ^[1] .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

PDS-0330

1 Cited Publications

Cat. No.: HY-153833

CAS No.: 2904682-19-3

Purity: 99.77%

Synonyms: KVA-E-23A

Target:

Gap Junction Protein

Research Areas:

Cancer

PDS-0330 is a specific and potent Claudin-1 inhibitor. PDS-0330 interferes with claudin-1/Src association and inhibits colorectal cancer (CRC) progression and metastasis ^[1].

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

Src Protein, Human (Active, His)

1 Cited Publications

Cat. No.: HY-P701321

Purity: ≥ 90%, as determined by reducing SDS-PAGE.

Synonyms: SRC; Tyrosine Kinase Pp60c-SRC; Prev. SRC1; P60-SRC; C-SRC; Protooncogene SRC, Rous Sarcoma; ASV; Tyrosine-Protein Kinase SRC-1; V-SRC Avian Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog; Pp60c-SRC; Proto-Oncogene Tyrosine-Protein Kinase SRC; THC6; SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase; Proto-Oncogene C-SRC

Species:

Human

Source:

E. coli

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

Phospho-Src (Tyr419) Antibody (YA150)

1 Cited Publications

Cat. No.: HY-P80514

Synonyms: SRC1, SRC, Proto-oncogene tyrosine-protein kinase SRC, Proto-oncogene c-SRC, pp60c-SRC, p60-SRC

Host:

Rabbit

Application:

WB, FC

Reactivity:

Human

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

SRC-1 NR box peptide

Cat. No.: HY-P5464

CAS No.: 227929-80-8

Target:

Estrogen Receptor/ERR

Research Areas:

Others

SRC-1 NR box peptide is a biological active peptide (This peptide is a 14-amino acid fragment from the steroid receptor cofactor SRC-1 NR II). SRC-1 NR box peptide can be used to study the regulatory mechanisms of estrogen receptor ligands ^[1].

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

SRC-1 NR box peptide acetate

Cat. No.: HY-P5464A

Target:

Estrogen Receptor/ERR

Research Areas:

Endocrinology

SRC-1 NR box peptide acetate is a biological active peptide (This peptide is a 14-amino acid fragment from the steroid receptor cofactor SRC-1 NR II). SRC-1 NR box peptide acetate can be used to study the regulatory mechanisms of estrogen receptor ligands ^[1].

Compare

loading...