60

Fatostatin

60 Publications Verification

Cat. No.: HY-14452

CAS No.: 125256-00-0

Purity: 99.85%

Synonyms: 125B11

Target:

Fatty Acid Synthase (FASN)

Research Areas:

Cancer

Fatostatin (125B11), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin decreases the transcription of lipogenic genes in cells. Fatostatin possesses antitumor properties, and lowers hyperglycemia in ob/ob mice .

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60

Fatostatin hydrobromide

60 Publications Verification

Cat. No.: HY-14452A

CAS No.: 298197-04-3

Purity: 99.52%

Synonyms: 125B11 hydrobromide

Target:

Fatty Acid Synthase (FASN)

Research Areas:

Cancer

Fatostatin hydrobromide (125B11 hydrobromide), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin hydrobromide binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin hydrobromide decreases the transcription of lipogenic genes in cells. Fatostatin hydrobromide possesses antitumor properties, and lowers hyperglycemia in ob/ob mice .

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16

Betulin

16 Cited Publications

Cat. No.: HY-N0083

CAS No.: 473-98-3

Synonyms: Trochol

Category:

Triterpenes Terpenoids Plants Other Families Extract Endogenous metabolite Disease Research Fields Cancer

Target:

Fatty Acid Synthase (FASN) Apoptosis Endogenous Metabolite

Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC₅₀ of 14.5 μM in K562 cell line .

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14

Olitigaltin

14 Cited Publications

Cat. No.: HY-19940

CAS No.: 1450824-22-2

Synonyms: TD139; GB0139

Target:

Galectin Akt β-catenin Apoptosis ERK

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Olitigaltin (TD139) is a high-affinity Galectin-3 inhibitor with a K_d value of 14 nM. Olitigaltin inhibits the activity of the AKT/β-catenin pathway, induces Apoptosis, and downregulates SREBP1 expression. Olitigaltin enhances the phosphorylation level of ERK. Olitigaltin alleviates bleomycin (HY-17565A)-induced advanced pulmonary fibrosis in mice. Olitigaltin delays the onset of diabetes, and improves glucose tolerance and serum insulin levels. Olitigaltin alleviates liver injury. Olitigaltin maintains the structure of hippocampal excitatory synapses, restores γ-wave power in the hippocampal CA1 region, inhibits hippocampal neuroinflammation, and improves cognitive function in neuroinflammation models. Olitigaltin can be used in research related to thyroid cancer, idiopathic pulmonary fibrosis, type 1 diabetes, hepatitis, and cognitive dysfunction induced by neuroinflammation .

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14

PF429242 dihydrochloride

14 Cited Publications

Cat. No.: HY-13447A

CAS No.: 2248666-66-0

Purity: 99.80%

Target:

Fatty Acid Synthase (FASN) Virus Protease

Research Areas:

Infection Metabolic Disease

PF429242 dihydrochloride is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC₅₀ of 175 nM .

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14

PF-429242

14 Cited Publications

Cat. No.: HY-13447

CAS No.: 947303-87-9

Target:

Fatty Acid Synthase (FASN) Virus Protease

Research Areas:

Infection Metabolic Disease

PF429242 is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC₅₀ of 175 nM .

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9

Cleaved-Caspase 3 p12 Antibody (YA499)

9 Cited Publications

Cat. No.: HY-P80623

Synonyms: CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1

Host:

Rabbit

Application:

WB, ICC/IF

Reactivity:

Human, Mouse, Rat

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6

Tauro-β-muricholic acid

6 Cited Publications

Cat. No.: HY-N9933

CAS No.: 25696-60-0

Synonyms: TβMCA

Category:

Human Gut Microbiota Metabolites Animals Endogenous metabolite Steroids

Target:

FXR Apoptosis

Tauro-β-muricholic acid (TβMCA) is an orally active trihydroxylated bile acid and a competitive, reversible FXR antagonist (IC₅₀=40 μM). Tauro-β-muricholic acid inhibits bile acid-induced hepatocyte apoptosis by maintaining mitochondrial membrane potential, while simultaneously inhibiting intestinal FXR signaling, affecting bile acid synthesis, hepatic lipid metabolism, and insulin sensitivity. Accumulation of tauro-β-muricholic acid disrupts metabolic homeostasis, promoting cancer stem cell proliferation and tumor progression. The mechanisms of tauro-β-muricholic acid involve two aspects: first, inhibiting the translocation of the pro-apoptotic protein Bax to mitochondria and maintaining mitochondrial membrane potential (MMP); and second, blocking the FXR signaling pathway to regulate bile acid metabolism, reduce serum ceramide production, and downregulate the hepatic SREBP1C/CIDEA pathway. Tauro-β-muricholic acid possesses anti-hepatocyte apoptosis, bile acid homeostasis regulation, and liver fat accumulation reduction properties, and also functions as a biomarker, making it useful in the study of diseases such as bile acid metabolism disorders, non-alcoholic fatty liver disease, colorectal cancer, and liver fibrosis .

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6

Taurolithocholic acid

6 Cited Publications

Cat. No.: HY-113308

CAS No.: 516-90-5

Purity: 98.06%

Target:

Calcium Channel Ferroptosis PI3K Akt HBV Reactive Oxygen Species (ROS)

Research Areas:

Cardiovascular Disease Infection Inflammation/Immunology

Taurolithocholic acid is an orally active bile acid and antiviral agent. Taurolithocholic acid upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis (Ferroptosis), viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis .

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6

Desmosterol

6 Cited Publications

Cat. No.: HY-113224

CAS No.: 313-04-2

Purity: ≥98.0%

Category:

Disease markers Metabolic Disease Endocrine diseases Endogenous metabolite Disease Research Fields Steroids

Target:

Endogenous Metabolite LXR Fatty Acid Synthase (FASN) Interleukin Related Reactive Oxygen Species (ROS) NOD-like Receptor (NLR)

Desmosterol is a cholesterol-like molecule. In the Bloch pathway of cholesterol biosynthesis, Desmosterol is a direct precursor of cholesterol. As an endogenous metabolite, Desmosterol is used to study cholesterol metabolism . Desmosterol is an LXR activator and SREBP inhibitor, which can suppress macrophage inflammasome activation and prevent vascular inflammation and atherosclerosis. A reduction in Desmosterol promotes the production of mitochondrial reactive oxygen species (ROS) in macrophages and pyrin domain-dependent inflammasome activation of NLRP3. Desmosterol holds potential for research in inflammation, metabolism, and cardiovascular diseases .

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6

Taurolithocholic acid sodium salt

6 Cited Publications

Cat. No.: HY-113308A

CAS No.: 6042-32-6

Purity: 99.81%

Category:

Animals Metabolic Disease Disease Research Fields Steroids

Target:

Calcium Channel Ferroptosis PI3K Reactive Oxygen Species (ROS) Akt HBV

Taurolithocholic acid sodium salt is an orally active bile acid and antiviral agent. Taurolithocholic acid sodium salt upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid sodium salt also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid sodium salt serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid sodium salt shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid sodium salt not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis .

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6

Sodium acetate trihydrate, meets analytical specification of Ph. Eur. BP USP FCC E262, ≤0.00002% Al

6 Cited Publications

Cat. No.: HY-Y1325H

CAS No.: 6131-90-4

Sodium acetate trihydrate, meets analytical specification of Ph. Eur. BP USP FCC E262, ≤0.00002% Al is a carboxylic acid and short-chain fatty acid (SCFAs). Sodium acetate trihydrate activates AMPK, increases ROS, cleaved caspase 9, PPARα, downregulates SREBP-1c, ChREBP expression. Sodium acetate trihydrate exhibits antifungal activity against Saccharomyces cerevisiae W303-1A. Sodium acetate trihydrate regulates energy metabolism. Sodium acetate trihydrate has anticancer activity against gastric cancer. Sodium acetate trihydrate induces writhing reaction and ulcerative colitis. Sodium acetate trihydrate can be used in the researches for gastric cancer, ulcerative colitis, hepatic steatosis, and pain .

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6

Caspase-3 Antibody (YA557)

6 Cited Publications

Cat. No.: HY-P80046

Synonyms: CPP32, CASP3, Caspase-3, CASP-3, Apopain, Cysteine protease CPP32, Protein Yama, SREBP cleavage activity 1, CPP-32, SCA-1

Host:

Rabbit

Application:

WB, ICC/IF, IHC-P, IP, FC

Reactivity:

Human

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6

Caspase-3/CASP3 Protein, Human

6 Cited Publications

Cat. No.: HY-P701341

Purity: ≥ 90%, as determined by reducing SDS-PAGE.

Synonyms: CASP3; Protein Yama; Caspase 3; Caspase-3; Apopain; CASP-3; CPP32; CPP-32; CPP32B; SCA-1; Caspase 3, Apoptosis-Related Cysteine Peptidase; Yama; Caspase 3, Apoptosis-Related Cysteine Protease; PARP Cleavage Protease; SREBP Cleavage Activity 1; Procaspase3

Species:

Human

Source:

E. coli

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