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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
STAT4
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "STAT4" in MCE Product Catalog:
3
3 Cited Publications
Cat. No.: HY-173236
Target:
Research Areas:
STAT4-IN-1 is an inhibitor of STAT4 with a Ki of 0.35 μM. STAT4-IN-1 is expected to be used in the research of autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes .
Synonyms: (R)-Lisophylline
Target:
Research Areas:
(R)-Lisofylline ((R)-Lisophylline) is a (R)-enantiomer of the metabolite of Pentoxifylline with anti-inflammatory properties. (R)-Lisofylline is a lysophosphatidic acid acyltransferase inhibitor with an IC50 of 0.6 μM and interrupts IL-12 signaling-mediated STAT4 activation. (R)-Lisofylline has the potential for type 1 diabetes, autoimmune disorders research .
Cat. No.: HY-169360
CAS No.: 2497585-50-7
SD-436 is a highly selective and efficacious STAT3 PROTAC degrader (DC50: 0.5 μM), with IC50 of 19 nM (STAT3), 270 nM (STAT1), 360 nM (STAT4), >10 μM (STAT5) and >10 μM (STAT6). SD-436 promotes ubiquitination and degradation of STAT3, and induces tumor regression. SD-436 can be used for tumor research, such as leukemia and lymphoma .
Cat. No.: HY-RS13891
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Research Areas:
STAT4 Human Pre-designed siRNA Set A contains three designed siRNAs for STAT4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17148
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Research Areas:
Stat4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stat4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23597
Target:
Research Areas:
Stat4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Stat4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P76664
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: STAT4; Signal Transducer And Activator Of Transcription; Signal Transducer And Activator Of Transcription 4; SLEB11; Signal Transducer And Activator Of Transcription 4 Variant 3; DPMC
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-189706
CAS No.: 3128949-21-0
Target:
Research Areas:
Stafori-2 is a selective STAT4 SH2 domain inhibitor. Stafori-2 binds to the STAT4 Src homology 2 (SH2) domain, blocking protein-protein interactions, with a human Ki value of 0.18 μM. Stafori-2 can be used in research related to autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and type 1 diabetes .
Cat. No.: HY-184833
CAS No.: 2417137-50-7
Research Areas:
Tyk2-IN-25 is a TYK2 inhibitor that binds to the JH2 domain of TYK2. Tyk2-IN-25 inhibits p-STAT4 and p-STAT3 in human peripheral blood mononuclear cells. Tyk2-IN-25 is applicable to research related to multiple diseases such as immune and inflammatory diseases, and neurological diseases .
Cat. No.: HY-109854AR
CAS No.: 100324-81-0
Synonyms: (R)-Lisophylline (Standard)
Target:
Research Areas:
(R)-Lisofylline (Standard) is the analytical standard of (R)-Lisofylline (HY-109854A). This product is intended for research and analytical applications. (R)-Lisofylline ((R)-Lisophylline) is a (R)-enantiomer of the metabolite of Pentoxifylline with anti-inflammatory properties. (R)-Lisofylline is a lysophosphatidic acid acyltransferase inhibitor with an IC50 of 0.6 μM and interrupts IL-12 signaling-mediated STAT4 activation. (R)-Lisofylline has the potential for type 1 diabetes, autoimmune disorders research .
Cat. No.: HY-L008
747 compounds
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).
MCE provides 747 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
