38 Results for "

SULTs

" in MedChemExpress (MCE) Product Catalog:
Products (38)

38 Results for "SULTs" in MCE Product Catalog:

2
7-Azido-4-methylcoumarin
7-Azido-4-methylcoumarin
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2 Cited Publications
Cat. No.: HY-119323
CAS No.: 95633-27-5
Purity:  99.11%
Target:  

Fluorescent Dye

Research Areas:  

Others

7-Azido-4-methylcoumarin is a selective coumarin-based fluorescent probe for hydrogen sulfide (H2S). In the presence of H2S, the aromatic azido group of 7-Azido-4-methylcoumarin is selectively reduced to produce the fluorescently active 7-amino-4-methylcoumarin (AMC). 7-Azido-4-methylcoumarin binds to the coumarin/phenol-binding site of BSA, the aglycone-binding site of UGT1A6, and the substrate-binding site of SULT1A1, respectively. 7-Azido-4-methylcoumarin retains its fluorescent properties after covalent binding, acts as a fluorescent H2S probe, and does not react with cysteine, homocysteine or glutathione (Ex/Em = 340/445 nm) .
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Dopamine 4-sulfate
Dopamine 4-sulfate
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Cat. No.: HY-113257
CAS No.: 38339-02-5
Synonyms: DA-4S; Dopamine 4-Sulfate
Target:  

Drug Metabolite

Research Areas:  

Neurological Disease

Dopamine 4-sulfate (DA-4S) is an inactive metabolite of the catecholamine dopamine. It is formed from dopamine by the sulfotransferase (SULT) isoform SULT1A3. Dopamine 4-O-sulfate is found at lower levels in the brain and circulation than dopamine 3-O-sulfate.
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Phenyl sulfate
Phenyl sulfate
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Cat. No.: HY-128442
CAS No.: 937-34-8
Purity:  99.56%
Synonyms: Phenyl hydrogen sulfate
Category:  

Human Gut Microbiota Metabolites Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

Phenyl sulfate (Phenyl hydrogen sulfate) is an orally active gut microbiota-derived metabolite. Phenyl sulfate undergoes hepatic sulfation via SULT1A1. Phenyl sulfate induces podocyte injury, albuminuria, renal pro-inflammatory and pro-fibrotic effects, cytotoxicity, glutathione depletion, mitochondrial dysfunction, and sensitizes renal tubular cells to oxidative stress. Phenyl sulfate can be used in research on diabetic nephropathy .
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(Rac)-Metanephrine hydrochloride
(Rac)-Metanephrine hydrochloride
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Cat. No.: HY-W012206
CAS No.: 881-95-8
(Rac)-Metanephrine hydrochloride is a metabolite of epinephrine and a substrate of the sulfotransferase SULT1A3. (Rac)-Metanephrine hydrochloride undergoes sulfonation at its p-hydroxyl group via a reaction catalyzed by SULT1A3. (Rac)-Metanephrine hydrochloride is an isomer of Metanephrine (HY-113299) hydrochloride, and it is applicable to the research of pheochromocytoma .
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12-Hydroxynevirapine
12-Hydroxynevirapine
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Cat. No.: HY-148642
CAS No.: 133627-24-4
Synonyms: 12-hydroxy-NVP; 12-OH-NVP
Target:  

Drug Metabolite

Research Areas:  

Infection

12-Hydroxynevirapine (12-hydroxy-NVP; 12-OH-NVP) is a major oxidative metabolite of Nevirapine (HY-10570). Nevirapine is a non-nucleoside reverse transcriptase inhibitor indicated for the HIV-1 infections. Nevirapine causes idiosyncratic hepatotoxicity and mild-to-severe skin rashes. 12-Hydroxynevirapine, a non-reactive metabolite, can be bioactivated by sulphotransferases (SULTs) in the liver and skin, yielding the reactive species 12-Sulphoxy-nevirapine .
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MI1013
MI1013
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Cat. No.: HY-175266
Target:  

PROTACs Cytochrome P450 Pregnane X Receptor (PXR)

Research Areas:  

Metabolic Disease

MI1013 is a PROTAC PXR degrader (DC50 = 89 nM, Dmax = 82%). MI1013 degrades PXR in human hepatocellular carcinoma RG cells (HepaRG). MI1013 specifically and safely regulates CYP3A4 promoter activity through PXR degradation. MI1013 affects several key genes involved in sulfate conjugation (e.g., SULT1E1), bile acid synthesis (CYP7A1), gluconeogenesis (PCK1), ketone synthesis (HMGCS20), and hepatocyte proliferation (MKI67). (Pink: PXR ligand 3: HY-175267, Blue: Pomalidomide-propargyl ligand: HY-W410002, Pink + Black: PXR ligand-Linker Conjugate 1: HY-175268) .
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4-Hydroxyphenylacetic acid (Standard)
4-Hydroxyphenylacetic acid (Standard)
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Cat. No.: HY-N1902R
CAS No.: 156-38-7
Category:  

Human Gut Microbiota Metabolites Monophenols Phenols Plants 500 - Internal Server Error | MedChemExpress

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